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Recombinant human GLP-1 beinaglutide regulates lipid metabolism of adipose tissues in diet-induced obese mice

GLP-1 analogs are a class of glucose-lowering agents with multiple benefits in diabetes, but its role in adipose tissues remains to be elucidated. The aim of this study was to determine the action of recombinant human GLP-1 (rhGLP-1) Beinaglutide (BN) in the insulin sensitivity and lipid metabolism...

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Autores principales: Zhang, Feng, Chen, Zhinan, Wu, Dan, Tian, Le, Chen, Qing, Ye, Yuqing, Chen, Wei, Wu, Xiaoxing, Wu, Peng, Yuan, Weilan, Qiu, Yan, Zhou, Zhiguang, Du, Zhiqiang, Hu, Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8605346/
https://www.ncbi.nlm.nih.gov/pubmed/34841227
http://dx.doi.org/10.1016/j.isci.2021.103382
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author Zhang, Feng
Chen, Zhinan
Wu, Dan
Tian, Le
Chen, Qing
Ye, Yuqing
Chen, Wei
Wu, Xiaoxing
Wu, Peng
Yuan, Weilan
Qiu, Yan
Zhou, Zhiguang
Du, Zhiqiang
Hu, Fang
author_facet Zhang, Feng
Chen, Zhinan
Wu, Dan
Tian, Le
Chen, Qing
Ye, Yuqing
Chen, Wei
Wu, Xiaoxing
Wu, Peng
Yuan, Weilan
Qiu, Yan
Zhou, Zhiguang
Du, Zhiqiang
Hu, Fang
author_sort Zhang, Feng
collection PubMed
description GLP-1 analogs are a class of glucose-lowering agents with multiple benefits in diabetes, but its role in adipose tissues remains to be elucidated. The aim of this study was to determine the action of recombinant human GLP-1 (rhGLP-1) Beinaglutide (BN) in the insulin sensitivity and lipid metabolism of adipose tissues. We have shown that, after BN injection, obese mice displayed lower body weight, fat mass, and plasma lipid levels. In addition, BN promoted the insulin sensitivity in the white adipose tissues. Furthermore, we have found that the BN treatment caused significant changes in content and composition of different lipid classes, including glycerolipids, glycerophospholipids, and sphingolipids, as well as expression of genes in lipid metabolic pathways in the adipose tissues. Taken together, our data demonstrate that BN could resist HFD-induced obesity by targeting the composition of major lipid classes and the expression of genes in lipid metabolism of adipose tissues.
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spelling pubmed-86053462021-11-26 Recombinant human GLP-1 beinaglutide regulates lipid metabolism of adipose tissues in diet-induced obese mice Zhang, Feng Chen, Zhinan Wu, Dan Tian, Le Chen, Qing Ye, Yuqing Chen, Wei Wu, Xiaoxing Wu, Peng Yuan, Weilan Qiu, Yan Zhou, Zhiguang Du, Zhiqiang Hu, Fang iScience Article GLP-1 analogs are a class of glucose-lowering agents with multiple benefits in diabetes, but its role in adipose tissues remains to be elucidated. The aim of this study was to determine the action of recombinant human GLP-1 (rhGLP-1) Beinaglutide (BN) in the insulin sensitivity and lipid metabolism of adipose tissues. We have shown that, after BN injection, obese mice displayed lower body weight, fat mass, and plasma lipid levels. In addition, BN promoted the insulin sensitivity in the white adipose tissues. Furthermore, we have found that the BN treatment caused significant changes in content and composition of different lipid classes, including glycerolipids, glycerophospholipids, and sphingolipids, as well as expression of genes in lipid metabolic pathways in the adipose tissues. Taken together, our data demonstrate that BN could resist HFD-induced obesity by targeting the composition of major lipid classes and the expression of genes in lipid metabolism of adipose tissues. Elsevier 2021-10-30 /pmc/articles/PMC8605346/ /pubmed/34841227 http://dx.doi.org/10.1016/j.isci.2021.103382 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Zhang, Feng
Chen, Zhinan
Wu, Dan
Tian, Le
Chen, Qing
Ye, Yuqing
Chen, Wei
Wu, Xiaoxing
Wu, Peng
Yuan, Weilan
Qiu, Yan
Zhou, Zhiguang
Du, Zhiqiang
Hu, Fang
Recombinant human GLP-1 beinaglutide regulates lipid metabolism of adipose tissues in diet-induced obese mice
title Recombinant human GLP-1 beinaglutide regulates lipid metabolism of adipose tissues in diet-induced obese mice
title_full Recombinant human GLP-1 beinaglutide regulates lipid metabolism of adipose tissues in diet-induced obese mice
title_fullStr Recombinant human GLP-1 beinaglutide regulates lipid metabolism of adipose tissues in diet-induced obese mice
title_full_unstemmed Recombinant human GLP-1 beinaglutide regulates lipid metabolism of adipose tissues in diet-induced obese mice
title_short Recombinant human GLP-1 beinaglutide regulates lipid metabolism of adipose tissues in diet-induced obese mice
title_sort recombinant human glp-1 beinaglutide regulates lipid metabolism of adipose tissues in diet-induced obese mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8605346/
https://www.ncbi.nlm.nih.gov/pubmed/34841227
http://dx.doi.org/10.1016/j.isci.2021.103382
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