Structure based prediction of a novel GPR120 antagonist based on pharmacophore screening and molecular dynamics simulations

The G-protein coupled receptor, GPR120, has ubiquitous expression and multifaceted roles in modulating metabolic and anti-inflammatory processes. Recent implications of its role in cancer progression have presented GPR120 as an attractive oncogenic drug target. GPR120 gene knockdown in breast cancer...

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Detalles Bibliográficos
Autores principales: Pal, Ajay, Curtin, James F., Kinsella, Gemma K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8605389/
https://www.ncbi.nlm.nih.gov/pubmed/34849208
http://dx.doi.org/10.1016/j.csbj.2021.11.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8605389/
https://www.ncbi.nlm.nih.gov/pubmed/34849208
http://dx.doi.org/10.1016/j.csbj.2021.11.005

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