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Extracellular vesicles in malaria: an agglomeration of two decades of research

Malaria is a complex parasitic disease, caused by Plasmodium spp. More than a century after the discovery of malaria parasites, this disease continues to pose a global public health problem and the pathogenesis of the severe forms of malaria remains incompletely understood. Extracellular vesicles (E...

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Autores principales: Opadokun, Tosin, Rohrbach, Petra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8605462/
https://www.ncbi.nlm.nih.gov/pubmed/34801056
http://dx.doi.org/10.1186/s12936-021-03969-8
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author Opadokun, Tosin
Rohrbach, Petra
author_facet Opadokun, Tosin
Rohrbach, Petra
author_sort Opadokun, Tosin
collection PubMed
description Malaria is a complex parasitic disease, caused by Plasmodium spp. More than a century after the discovery of malaria parasites, this disease continues to pose a global public health problem and the pathogenesis of the severe forms of malaria remains incompletely understood. Extracellular vesicles (EVs), including exosomes and microvesicles, have been increasingly researched in the field of malaria in a bid to fill these knowledge gaps. EVs released from Plasmodium-infected red blood cells and other host cells during malaria infection are now believed to play key roles in disease pathogenesis and are suggested as vital components of the biology of Plasmodium spp. Malaria-derived EVs have been identified as potential disease biomarkers and therapeutic tools. In this review, key findings of malaria EV studies over the last 20 years are summarized and critically analysed. Outstanding areas of research into EV biology are identified. Unexplored EV research foci for the future that will contribute to consolidating the potential for EVs as agents in malaria prevention and control are proposed.
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spelling pubmed-86054622021-11-22 Extracellular vesicles in malaria: an agglomeration of two decades of research Opadokun, Tosin Rohrbach, Petra Malar J Review Malaria is a complex parasitic disease, caused by Plasmodium spp. More than a century after the discovery of malaria parasites, this disease continues to pose a global public health problem and the pathogenesis of the severe forms of malaria remains incompletely understood. Extracellular vesicles (EVs), including exosomes and microvesicles, have been increasingly researched in the field of malaria in a bid to fill these knowledge gaps. EVs released from Plasmodium-infected red blood cells and other host cells during malaria infection are now believed to play key roles in disease pathogenesis and are suggested as vital components of the biology of Plasmodium spp. Malaria-derived EVs have been identified as potential disease biomarkers and therapeutic tools. In this review, key findings of malaria EV studies over the last 20 years are summarized and critically analysed. Outstanding areas of research into EV biology are identified. Unexplored EV research foci for the future that will contribute to consolidating the potential for EVs as agents in malaria prevention and control are proposed. BioMed Central 2021-11-20 /pmc/articles/PMC8605462/ /pubmed/34801056 http://dx.doi.org/10.1186/s12936-021-03969-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Opadokun, Tosin
Rohrbach, Petra
Extracellular vesicles in malaria: an agglomeration of two decades of research
title Extracellular vesicles in malaria: an agglomeration of two decades of research
title_full Extracellular vesicles in malaria: an agglomeration of two decades of research
title_fullStr Extracellular vesicles in malaria: an agglomeration of two decades of research
title_full_unstemmed Extracellular vesicles in malaria: an agglomeration of two decades of research
title_short Extracellular vesicles in malaria: an agglomeration of two decades of research
title_sort extracellular vesicles in malaria: an agglomeration of two decades of research
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8605462/
https://www.ncbi.nlm.nih.gov/pubmed/34801056
http://dx.doi.org/10.1186/s12936-021-03969-8
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