Making memories with Bcl-6

For over a decade, mutual antagonism between the transcriptional repressors Bcl-6 and Blimp-1 has been appreciated as a key mechanistic determinant of lymphoid differentiation programs. Now, in this issue of JEM, Ciucci et al. (2021. J. Exp. Med. https://doi.org/10.1084/jem.20202343) demonstrate tha...

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Detalles Bibliográficos
Autores principales: Read, Kaitlin A., Oestreich, Kenneth J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Insights
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8605494/
https://www.ncbi.nlm.nih.gov/pubmed/34792529
http://dx.doi.org/10.1084/jem.20212177
Descripción
Sumario:For over a decade, mutual antagonism between the transcriptional repressors Bcl-6 and Blimp-1 has been appreciated as a key mechanistic determinant of lymphoid differentiation programs. Now, in this issue of JEM, Ciucci et al. (2021. J. Exp. Med. https://doi.org/10.1084/jem.20202343) demonstrate that this relationship is "central" to the generation of T cell memory.

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