Dependence on Bcl6 and Blimp1 drive distinct differentiation of murine memory and follicular helper CD4(+) T cells

During the immune response, CD4(+) T cells differentiate into distinct effector subtypes, including follicular helper T (Tfh) cells that help B cells, and into memory cells. Tfh and memory cells are required for long-term immunity; both depend on the transcription factor Bcl6, raising the question w...

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Detalles Bibliográficos
Autores principales: Ciucci, Thomas, Vacchio, Melanie S., Chen, Ting, Nie, Jia, Chopp, Laura B., McGavern, Dorian B., Kelly, Michael C., Bosselut, Rémy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8605495/
https://www.ncbi.nlm.nih.gov/pubmed/34792530
http://dx.doi.org/10.1084/jem.20202343

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