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α-Synuclein-mediated neurodegeneration in Dementia with Lewy bodies: the pathobiology of a paradox

Dementia with Lewy bodies (DLB) is epitomized by the pathognomonic manifestation of α-synuclein-laden Lewy bodies within selectively vulnerable neurons in the brain. By virtue of prion-like inheritance, the α-synuclein protein inexorably undergoes extensive conformational metamorphoses and culminate...

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Detalles Bibliográficos
Autores principales:	Simon, Christopher, Soga, Tomoko, Okano, Hirotaka James, Parhar, Ishwar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8605528/ https://www.ncbi.nlm.nih.gov/pubmed/34798911 http://dx.doi.org/10.1186/s13578-021-00709-y

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