The genotypic and phenotypic impact of hypoxia microenvironment on glioblastoma cell lines

BACKGROUND: Glioblastoma is a fatal brain tumour with a poor patient survival outcome. Hypoxia has been shown to reprogram cells towards a stem cell phenotype associated with self-renewal and drug resistance properties. Activation of hypoxia-inducible factors (HIFs) helps in cellular adaptation mech...

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Detalles Bibliográficos
Autores principales: Macharia, Lucy Wanjiku, Muriithi, Wanjiru, Heming, Carlos Pilotto, Nyaga, Dennis Kirii, Aran, Veronica, Mureithi, Marianne Wanjiru, Ferrer, Valeria Pereira, Pane, Attilio, Filho, Paulo Niemeyer, Moura-Neto, Vivaldo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8605580/
https://www.ncbi.nlm.nih.gov/pubmed/34798868
http://dx.doi.org/10.1186/s12885-021-08978-z

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