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Remodeling of the tumor microenvironment via disrupting Blimp1(+) effector Treg activity augments response to anti-PD-1 blockade

BACKGROUND: Accumulation of Foxp3(+) regulatory T (Treg) cells in the tumor often represents an important mechanism for cancer immune evasion and a critical barrier to anti-tumor immunity and immunotherapy. Many tumor-infiltrating Treg cells display an activated phenotype and express the transcripti...

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Detalles Bibliográficos
Autores principales:	Dixon, Michael L., Luo, Lin, Ghosh, Sadashib, Grimes, Jeffrey M., Leavenworth, Jonathan D., Leavenworth, Jianmei W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8605582/ https://www.ncbi.nlm.nih.gov/pubmed/34798898 http://dx.doi.org/10.1186/s12943-021-01450-3

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