Cargando…

Remodeling of the tumor microenvironment via disrupting Blimp1(+) effector Treg activity augments response to anti-PD-1 blockade

BACKGROUND: Accumulation of Foxp3(+) regulatory T (Treg) cells in the tumor often represents an important mechanism for cancer immune evasion and a critical barrier to anti-tumor immunity and immunotherapy. Many tumor-infiltrating Treg cells display an activated phenotype and express the transcripti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dixon, Michael L., Luo, Lin, Ghosh, Sadashib, Grimes, Jeffrey M., Leavenworth, Jonathan D., Leavenworth, Jianmei W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8605582/ https://www.ncbi.nlm.nih.gov/pubmed/34798898 http://dx.doi.org/10.1186/s12943-021-01450-3

Ejemplares similares

Lineage Reprogramming of Effector Regulatory T Cells in Cancer
por: Dixon, Michael L., et al.
Publicado: (2021)

NFATc1/αA and Blimp-1 Support the Follicular and Effector Phenotype of Tregs
por: Koenig, Anika, et al.
Publicado: (2022)

Control of Germinal Center Localization and Lineage Stability of Follicular Regulatory T Cells by the Blimp1 Transcription Factor
por: Shen, Erxia, et al.
Publicado: (2020)

Control of Germinal Center Localization and Lineage Stability of Follicular Regulatory T Cells by the Blimp1 Transcription Factor
por: Shen, Erxia, et al.
Publicado: (2019)

Targeting the TREM1-positive myeloid microenvironment in glioblastoma
por: Filippova, Natalia, et al.
Publicado: (2022)

AIMing 2 promote lupus by targeting helpers
por: Leavenworth, Jianmei W.
Publicado: (2022)

Contribution of Dysregulated B-Cells and IgE Antibody Responses to Multiple Sclerosis
por: Seals, Malik R., et al.
Publicado: (2022)

Treg-Dominant Tumor Microenvironment Is Responsible for Hyperprogressive Disease after PD-1 Blockade Therapy
por: Wakiyama, Hiroaki, et al.
Publicado: (2022)

Differential regulation of Effector and Regulatory T cell function by Blimp1
por: Bankoti, Rashmi, et al.
Publicado: (2017)

The Role of Microglia and Macrophages in CNS Homeostasis, Autoimmunity, and Cancer
por: Yin, Jie, et al.
Publicado: (2017)

Dysregulated follicular regulatory T cells and antibody responses exacerbate experimental autoimmune encephalomyelitis
por: Luo, Lin, et al.
Publicado: (2021)

Blockade of Treg derived TGF-β abrogates suppression of effector T cell function within the tumor microenvironment
por: Budhu, Sadna, et al.
Publicado: (2013)

Modulation of the Intratumoral Immune Landscape by Oncolytic Herpes Simplex Virus Virotherapy
por: Yin, Jie, et al.
Publicado: (2017)

Tregs facilitate obesity and insulin resistance via a Blimp-1/IL-10 axis
por: Beppu, Lisa Y., et al.
Publicado: (2021)

Role of Blimp-1 in programing Th effector cells into IL-10 producers
por: Neumann, Christian, et al.
Publicado: (2014)

Blockade of surface bound TGF-β abrogates Treg suppression of effector T cell function within the tumor microenvironment
por: Budhu, Sadna, et al.
Publicado: (2014)

RNF2 ablation reprograms the tumor-immune microenvironment and stimulates durable NK and CD4(+) T-cell-dependent antitumor immunity
por: Zhang, Zhuo, et al.
Publicado: (2021)

Analysis of Blimp-1 and PD-1/PD-L1 Immune Checkpoint in an Autoimmune Thyroiditis Animal Model
por: Zhang, Xue, et al.
Publicado: (2020)

Editorial: Immune Cell Lineage Reprogramming in Cancer
por: Leavenworth, Jianmei W., et al.
Publicado: (2022)

A p85α–osteopontin axis couples the ICOS receptor to sustained Bcl-6 expression by follicular helper and regulatory T cells
por: Leavenworth, Jianmei W., et al.
Publicado: (2014)

Editorial: Dendritic cell-primed T cells in anti-tumor immune responses and relevant vaccine strategies
por: Leavenworth, Jianmei W., et al.
Publicado: (2022)

New insights into Blimp-1 in T lymphocytes: a divergent regulator of cell destiny and effector function
por: Fu, Shin-Huei, et al.
Publicado: (2017)

Blockade of LFA-1 augments in vitro differentiation of antigen-induced Foxp3(+) Treg cells
por: Verhagen, Johan, et al.
Publicado: (2014)

Drug-loaded microbubble delivery system to enhance PD-L1 blockade immunotherapy with remodeling immune microenvironment
por: Zheng, Jun, et al.
Publicado: (2023)

Cochaperone Mzb1 is a key effector of Blimp1 in plasma cell differentiation and β1-integrin function
por: Andreani, Virginia, et al.
Publicado: (2018)

Angiostrongylus cantonensis Galectin-1 interacts with Annexin A2 to impair the viability of macrophages via activating JNK pathway
por: Shi, Xiaomeng, et al.
Publicado: (2020)

Blimp-1 and systemic lupus erythematosus
por: Diamond, Betty, et al.
Publicado: (2014)

Selective inhibition of TGF-β1 produced by GARP-expressing Tregs overcomes resistance to PD-1/PD-L1 blockade in cancer
por: de Streel, Grégoire, et al.
Publicado: (2020)

Towards Clinical Translation of CD8(+) Regulatory T Cells Restricted by Non-Classical Major Histocompatibility Complex Ib Molecules
por: Wasnik, Samiksha, et al.
Publicado: (2019)

Editorial: Macrophage immunity and metabolism in cancer: Novel diagnostic and therapeutic strategies
por: Leavenworth, Jianmei W., et al.
Publicado: (2022)

Remodeling the tumor microenvironment via blockade of LAIR-1 and TGF-β signaling enables PD-L1–mediated tumor eradication
por: Horn, Lucas A., et al.
Publicado: (2022)

Selecting suitable chemotherapies for PD-1/PD-L1 blockade to optimize the tumor immune microenvironment
por: Koyama, Shohei, et al.
Publicado: (2018)

Sequential delivery of PD-1/PD-L1 blockade peptide and IDO inhibitor for immunosuppressive microenvironment remodeling via an MMP-2 responsive dual-targeting liposome
por: Hu, Chuan, et al.
Publicado: (2023)

Metabolic and functional reprogramming of myeloid-derived suppressor cells and their therapeutic control in glioblastoma
por: Won, Woong-Jai, et al.
Publicado: (2019)

Decitabine Augments Chemotherapy-Induced PD-L1 Upregulation for PD-L1 Blockade in Colorectal Cancer
por: Huang, Kevin Chih-Yang, et al.
Publicado: (2020)

Blimp-1 impairs T cell function via upregulation of TIGIT and PD-1 in patients with acute myeloid leukemia
por: Zhu, Liuluan, et al.
Publicado: (2017)

Tolerogenic function of Blimp-1 in dendritic cells
por: Kim, Sun Jung, et al.
Publicado: (2011)

Tolerogenic function of Blimp-1 in dendritic cells
por: Kim, Sun Jung, et al.
Publicado: (2012)

Ambra1 modulates the tumor immune microenvironment and response to PD-1 blockade in melanoma
por: Frias, Alex, et al.
Publicado: (2023)

Gegen Qinlian decoction enhances the effect of PD-1 blockade in colorectal cancer with microsatellite stability by remodelling the gut microbiota and the tumour microenvironment
por: Lv, Ji, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_1e1qnnie1t6g6rggmnj3j14rnt