Cargando…

Cytotoxicity of synthetic derivatives against breast cancer and multi-drug resistant breast cancer cell lines: a literature-based perspective study

Cancer is the second most killer worldwide causing millions of people to lose their lives every year. In the case of women, breast cancer takes away the highest proportion of mortality rate than other cancers. Due to the mutation and resistance-building capacity of different breast cancer cell lines...

Descripción completa

Detalles Bibliográficos
Autores principales: Sharmin, Shabnam, Rahaman, Md. Mizanur, Martorell, Miquel, Sastre-Serra, Jorge, Sharifi-Rad, Javad, Butnariu, Monica, Bagiu, Iulia Cristina, Bagiu, Radu Vasile, Islam, Mohammad Torequl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8606078/
https://www.ncbi.nlm.nih.gov/pubmed/34801046
http://dx.doi.org/10.1186/s12935-021-02309-9
_version_ 1784602277921685504
author Sharmin, Shabnam
Rahaman, Md. Mizanur
Martorell, Miquel
Sastre-Serra, Jorge
Sharifi-Rad, Javad
Butnariu, Monica
Bagiu, Iulia Cristina
Bagiu, Radu Vasile
Islam, Mohammad Torequl
author_facet Sharmin, Shabnam
Rahaman, Md. Mizanur
Martorell, Miquel
Sastre-Serra, Jorge
Sharifi-Rad, Javad
Butnariu, Monica
Bagiu, Iulia Cristina
Bagiu, Radu Vasile
Islam, Mohammad Torequl
author_sort Sharmin, Shabnam
collection PubMed
description Cancer is the second most killer worldwide causing millions of people to lose their lives every year. In the case of women, breast cancer takes away the highest proportion of mortality rate than other cancers. Due to the mutation and resistance-building capacity of different breast cancer cell lines against conventional therapies, this death rate is on the verge of growth. New effective therapeutic compounds and treatment method is the best way to look out for in this critical time. For instance, new synthetic derivatives/ analogues synthesized from different compounds can be a ray of hope. Numerous synthetic compounds have been seen enhancing the apoptosis and autophagic pathway that directly exerts cytotoxicity towards different breast cancer cell lines. To cease the ever-growing resistance of multi-drug resistant cells against anti-breast cancer drugs (Doxorubicin, verapamil, tamoxifen) synthetic compounds may play a vital role by increasing effectivity, showing synergistic action. Many recent and previous studies have reported that synthetic derivatives hold potentials as an effective anti-breast cancer agent as they show great cytotoxicity towards cancer cells, thus can be used even vastly in the future in the field of breast cancer treatment. This review aims to identify the anti-breast cancer properties of several synthetic derivatives against different breast cancer and multi-drug-resistant breast cancer cell lines with their reported mechanism of action and effectivity.
format Online
Article
Text
id pubmed-8606078
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-86060782021-11-22 Cytotoxicity of synthetic derivatives against breast cancer and multi-drug resistant breast cancer cell lines: a literature-based perspective study Sharmin, Shabnam Rahaman, Md. Mizanur Martorell, Miquel Sastre-Serra, Jorge Sharifi-Rad, Javad Butnariu, Monica Bagiu, Iulia Cristina Bagiu, Radu Vasile Islam, Mohammad Torequl Cancer Cell Int Review Cancer is the second most killer worldwide causing millions of people to lose their lives every year. In the case of women, breast cancer takes away the highest proportion of mortality rate than other cancers. Due to the mutation and resistance-building capacity of different breast cancer cell lines against conventional therapies, this death rate is on the verge of growth. New effective therapeutic compounds and treatment method is the best way to look out for in this critical time. For instance, new synthetic derivatives/ analogues synthesized from different compounds can be a ray of hope. Numerous synthetic compounds have been seen enhancing the apoptosis and autophagic pathway that directly exerts cytotoxicity towards different breast cancer cell lines. To cease the ever-growing resistance of multi-drug resistant cells against anti-breast cancer drugs (Doxorubicin, verapamil, tamoxifen) synthetic compounds may play a vital role by increasing effectivity, showing synergistic action. Many recent and previous studies have reported that synthetic derivatives hold potentials as an effective anti-breast cancer agent as they show great cytotoxicity towards cancer cells, thus can be used even vastly in the future in the field of breast cancer treatment. This review aims to identify the anti-breast cancer properties of several synthetic derivatives against different breast cancer and multi-drug-resistant breast cancer cell lines with their reported mechanism of action and effectivity. BioMed Central 2021-11-20 /pmc/articles/PMC8606078/ /pubmed/34801046 http://dx.doi.org/10.1186/s12935-021-02309-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Sharmin, Shabnam
Rahaman, Md. Mizanur
Martorell, Miquel
Sastre-Serra, Jorge
Sharifi-Rad, Javad
Butnariu, Monica
Bagiu, Iulia Cristina
Bagiu, Radu Vasile
Islam, Mohammad Torequl
Cytotoxicity of synthetic derivatives against breast cancer and multi-drug resistant breast cancer cell lines: a literature-based perspective study
title Cytotoxicity of synthetic derivatives against breast cancer and multi-drug resistant breast cancer cell lines: a literature-based perspective study
title_full Cytotoxicity of synthetic derivatives against breast cancer and multi-drug resistant breast cancer cell lines: a literature-based perspective study
title_fullStr Cytotoxicity of synthetic derivatives against breast cancer and multi-drug resistant breast cancer cell lines: a literature-based perspective study
title_full_unstemmed Cytotoxicity of synthetic derivatives against breast cancer and multi-drug resistant breast cancer cell lines: a literature-based perspective study
title_short Cytotoxicity of synthetic derivatives against breast cancer and multi-drug resistant breast cancer cell lines: a literature-based perspective study
title_sort cytotoxicity of synthetic derivatives against breast cancer and multi-drug resistant breast cancer cell lines: a literature-based perspective study
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8606078/
https://www.ncbi.nlm.nih.gov/pubmed/34801046
http://dx.doi.org/10.1186/s12935-021-02309-9
work_keys_str_mv AT sharminshabnam cytotoxicityofsyntheticderivativesagainstbreastcancerandmultidrugresistantbreastcancercelllinesaliteraturebasedperspectivestudy
AT rahamanmdmizanur cytotoxicityofsyntheticderivativesagainstbreastcancerandmultidrugresistantbreastcancercelllinesaliteraturebasedperspectivestudy
AT martorellmiquel cytotoxicityofsyntheticderivativesagainstbreastcancerandmultidrugresistantbreastcancercelllinesaliteraturebasedperspectivestudy
AT sastreserrajorge cytotoxicityofsyntheticderivativesagainstbreastcancerandmultidrugresistantbreastcancercelllinesaliteraturebasedperspectivestudy
AT sharifiradjavad cytotoxicityofsyntheticderivativesagainstbreastcancerandmultidrugresistantbreastcancercelllinesaliteraturebasedperspectivestudy
AT butnariumonica cytotoxicityofsyntheticderivativesagainstbreastcancerandmultidrugresistantbreastcancercelllinesaliteraturebasedperspectivestudy
AT bagiuiuliacristina cytotoxicityofsyntheticderivativesagainstbreastcancerandmultidrugresistantbreastcancercelllinesaliteraturebasedperspectivestudy
AT bagiuraduvasile cytotoxicityofsyntheticderivativesagainstbreastcancerandmultidrugresistantbreastcancercelllinesaliteraturebasedperspectivestudy
AT islammohammadtorequl cytotoxicityofsyntheticderivativesagainstbreastcancerandmultidrugresistantbreastcancercelllinesaliteraturebasedperspectivestudy