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Burden of nosocomial COVID-19 in Wales: results from a multicentre retrospective observational study of 2508 hospitalised adults

The burden of nosocomial SARS-CoV-2 infection remains poorly defined. We report on the outcomes of 2508 adults with molecularly-confirmed SARS-CoV-2 admitted across 18 major hospitals, representing over 60% of those hospitalised across Wales between 1 March and 1 July 2020. Inpatient mortality for n...

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Autores principales: Ponsford, Mark J, Jefferies, Rhys, Davies, Chris, Farewell, Daniel, Humphreys, Ian R, Jolles, Stephen, Fairbairn, Sara, Lewis, Keir, Menzies, Daniel, Benjamin, Amit, Thaivalappil, Favas, Williams, Chris, Barry, Simon M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8606436/
https://www.ncbi.nlm.nih.gov/pubmed/34301738
http://dx.doi.org/10.1136/thoraxjnl-2021-216964
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author Ponsford, Mark J
Jefferies, Rhys
Davies, Chris
Farewell, Daniel
Humphreys, Ian R
Jolles, Stephen
Fairbairn, Sara
Lewis, Keir
Menzies, Daniel
Benjamin, Amit
Thaivalappil, Favas
Williams, Chris
Barry, Simon M
author_facet Ponsford, Mark J
Jefferies, Rhys
Davies, Chris
Farewell, Daniel
Humphreys, Ian R
Jolles, Stephen
Fairbairn, Sara
Lewis, Keir
Menzies, Daniel
Benjamin, Amit
Thaivalappil, Favas
Williams, Chris
Barry, Simon M
author_sort Ponsford, Mark J
collection PubMed
description The burden of nosocomial SARS-CoV-2 infection remains poorly defined. We report on the outcomes of 2508 adults with molecularly-confirmed SARS-CoV-2 admitted across 18 major hospitals, representing over 60% of those hospitalised across Wales between 1 March and 1 July 2020. Inpatient mortality for nosocomial infection ranged from 38% to 42%, consistently higher than participants with community-acquired infection (31%–35%) across a range of case definitions. Those with hospital-acquired infection were older and frailer than those infected within the community. Nosocomial diagnosis occurred a median of 30 days following admission (IQR 21–63), suggesting a window for prophylactic or postexposure interventions, alongside enhanced infection control measures.
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spelling pubmed-86064362021-12-03 Burden of nosocomial COVID-19 in Wales: results from a multicentre retrospective observational study of 2508 hospitalised adults Ponsford, Mark J Jefferies, Rhys Davies, Chris Farewell, Daniel Humphreys, Ian R Jolles, Stephen Fairbairn, Sara Lewis, Keir Menzies, Daniel Benjamin, Amit Thaivalappil, Favas Williams, Chris Barry, Simon M Thorax Brief Communication The burden of nosocomial SARS-CoV-2 infection remains poorly defined. We report on the outcomes of 2508 adults with molecularly-confirmed SARS-CoV-2 admitted across 18 major hospitals, representing over 60% of those hospitalised across Wales between 1 March and 1 July 2020. Inpatient mortality for nosocomial infection ranged from 38% to 42%, consistently higher than participants with community-acquired infection (31%–35%) across a range of case definitions. Those with hospital-acquired infection were older and frailer than those infected within the community. Nosocomial diagnosis occurred a median of 30 days following admission (IQR 21–63), suggesting a window for prophylactic or postexposure interventions, alongside enhanced infection control measures. BMJ Publishing Group 2021-12 2021-07-22 /pmc/articles/PMC8606436/ /pubmed/34301738 http://dx.doi.org/10.1136/thoraxjnl-2021-216964 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
spellingShingle Brief Communication
Ponsford, Mark J
Jefferies, Rhys
Davies, Chris
Farewell, Daniel
Humphreys, Ian R
Jolles, Stephen
Fairbairn, Sara
Lewis, Keir
Menzies, Daniel
Benjamin, Amit
Thaivalappil, Favas
Williams, Chris
Barry, Simon M
Burden of nosocomial COVID-19 in Wales: results from a multicentre retrospective observational study of 2508 hospitalised adults
title Burden of nosocomial COVID-19 in Wales: results from a multicentre retrospective observational study of 2508 hospitalised adults
title_full Burden of nosocomial COVID-19 in Wales: results from a multicentre retrospective observational study of 2508 hospitalised adults
title_fullStr Burden of nosocomial COVID-19 in Wales: results from a multicentre retrospective observational study of 2508 hospitalised adults
title_full_unstemmed Burden of nosocomial COVID-19 in Wales: results from a multicentre retrospective observational study of 2508 hospitalised adults
title_short Burden of nosocomial COVID-19 in Wales: results from a multicentre retrospective observational study of 2508 hospitalised adults
title_sort burden of nosocomial covid-19 in wales: results from a multicentre retrospective observational study of 2508 hospitalised adults
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8606436/
https://www.ncbi.nlm.nih.gov/pubmed/34301738
http://dx.doi.org/10.1136/thoraxjnl-2021-216964
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