Arecoline Enhances Phosphodiesterase 4A Activity to Promote Transforming Growth Factor-β-Induced Buccal Mucosal Fibroblast Activation via cAMP-Epac1 Signaling Pathway

Chewing areca nut (betel quid) is strongly associated with oral submucous fibrosis (OSF), a pre-cancerous lesion. Among the areca alkaloids, arecoline is the main agent responsible for fibroblast proliferation; however, the specific molecular mechanism of arecoline affecting the OSF remains unclear....

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Detalles Bibliográficos
Autores principales: Zhang, Bo, Gao, Lihua, Shao, Chunsheng, Deng, Mingsi, Chen, Liangjian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8606562/
https://www.ncbi.nlm.nih.gov/pubmed/34819854
http://dx.doi.org/10.3389/fphar.2021.722040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8606562/
https://www.ncbi.nlm.nih.gov/pubmed/34819854
http://dx.doi.org/10.3389/fphar.2021.722040

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