Cargando…

Association between serum PGE(2) levels and degree of acid-fast bacilli positivity in sputum of pulmonary tuberculosis patients

BACKGROUND: Mycobacterium tuberculosis that infected apoptotic macrophages is triggered by PGE(2). Apoptosis suppresses the growth of Mycobacterium tuberculosis bacteria, which is shown in the results of acid-fast bacilli (AFB) in the sputum that becomes a marker of the number of bacteria. OBJECTIVE...

Descripción completa

Detalles Bibliográficos
Autores principales: Setiawan, Herley Windo, Yudhawati, Resti, Syafaah, Irmi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8606836/
https://www.ncbi.nlm.nih.gov/pubmed/34840758
http://dx.doi.org/10.1016/j.amsu.2021.103008
_version_ 1784602420802748416
author Setiawan, Herley Windo
Yudhawati, Resti
Syafaah, Irmi
author_facet Setiawan, Herley Windo
Yudhawati, Resti
Syafaah, Irmi
author_sort Setiawan, Herley Windo
collection PubMed
description BACKGROUND: Mycobacterium tuberculosis that infected apoptotic macrophages is triggered by PGE(2). Apoptosis suppresses the growth of Mycobacterium tuberculosis bacteria, which is shown in the results of acid-fast bacilli (AFB) in the sputum that becomes a marker of the number of bacteria. OBJECTIVE: Analyzing the association between serum PGE(2) levels and the positivity of AFB in the sputum of tuberculosis patients. METHODS: A cross-sectional study was carried out from August 2019–July 2020. Serum PGE(2) levels and AFB levels in sputum were collected from participants. Data analysis used the Chi-square test and Spearman's correlation with p < 0.05. RESULTS: The average participants’ serum PGE(2) levels were 446.37 ± 510.27 pg/ml, with a median value of 216.95 pg/ml. Most participants had normal serum PGE(2) levels (62.9%). Most participants had a high positivity of AFB in sputum (58.1%). Analysis of the association between serum PGE(2) levels and the degree of AFB positivity in sputum obtained r = −0.036 and p-value = 0.780. CONCLUSION: There is a weak negative association between serum PGE(2) levels and the degree of AFB positivity in sputum but not statistically significant.
format Online
Article
Text
id pubmed-8606836
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-86068362021-11-26 Association between serum PGE(2) levels and degree of acid-fast bacilli positivity in sputum of pulmonary tuberculosis patients Setiawan, Herley Windo Yudhawati, Resti Syafaah, Irmi Ann Med Surg (Lond) Cross-sectional Study BACKGROUND: Mycobacterium tuberculosis that infected apoptotic macrophages is triggered by PGE(2). Apoptosis suppresses the growth of Mycobacterium tuberculosis bacteria, which is shown in the results of acid-fast bacilli (AFB) in the sputum that becomes a marker of the number of bacteria. OBJECTIVE: Analyzing the association between serum PGE(2) levels and the positivity of AFB in the sputum of tuberculosis patients. METHODS: A cross-sectional study was carried out from August 2019–July 2020. Serum PGE(2) levels and AFB levels in sputum were collected from participants. Data analysis used the Chi-square test and Spearman's correlation with p < 0.05. RESULTS: The average participants’ serum PGE(2) levels were 446.37 ± 510.27 pg/ml, with a median value of 216.95 pg/ml. Most participants had normal serum PGE(2) levels (62.9%). Most participants had a high positivity of AFB in sputum (58.1%). Analysis of the association between serum PGE(2) levels and the degree of AFB positivity in sputum obtained r = −0.036 and p-value = 0.780. CONCLUSION: There is a weak negative association between serum PGE(2) levels and the degree of AFB positivity in sputum but not statistically significant. Elsevier 2021-11-03 /pmc/articles/PMC8606836/ /pubmed/34840758 http://dx.doi.org/10.1016/j.amsu.2021.103008 Text en © 2021 Published by Elsevier Ltd on behalf of IJS Publishing Group Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Cross-sectional Study
Setiawan, Herley Windo
Yudhawati, Resti
Syafaah, Irmi
Association between serum PGE(2) levels and degree of acid-fast bacilli positivity in sputum of pulmonary tuberculosis patients
title Association between serum PGE(2) levels and degree of acid-fast bacilli positivity in sputum of pulmonary tuberculosis patients
title_full Association between serum PGE(2) levels and degree of acid-fast bacilli positivity in sputum of pulmonary tuberculosis patients
title_fullStr Association between serum PGE(2) levels and degree of acid-fast bacilli positivity in sputum of pulmonary tuberculosis patients
title_full_unstemmed Association between serum PGE(2) levels and degree of acid-fast bacilli positivity in sputum of pulmonary tuberculosis patients
title_short Association between serum PGE(2) levels and degree of acid-fast bacilli positivity in sputum of pulmonary tuberculosis patients
title_sort association between serum pge(2) levels and degree of acid-fast bacilli positivity in sputum of pulmonary tuberculosis patients
topic Cross-sectional Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8606836/
https://www.ncbi.nlm.nih.gov/pubmed/34840758
http://dx.doi.org/10.1016/j.amsu.2021.103008
work_keys_str_mv AT setiawanherleywindo associationbetweenserumpge2levelsanddegreeofacidfastbacillipositivityinsputumofpulmonarytuberculosispatients
AT yudhawatiresti associationbetweenserumpge2levelsanddegreeofacidfastbacillipositivityinsputumofpulmonarytuberculosispatients
AT syafaahirmi associationbetweenserumpge2levelsanddegreeofacidfastbacillipositivityinsputumofpulmonarytuberculosispatients