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Association between serum PGE(2) levels and degree of acid-fast bacilli positivity in sputum of pulmonary tuberculosis patients
BACKGROUND: Mycobacterium tuberculosis that infected apoptotic macrophages is triggered by PGE(2). Apoptosis suppresses the growth of Mycobacterium tuberculosis bacteria, which is shown in the results of acid-fast bacilli (AFB) in the sputum that becomes a marker of the number of bacteria. OBJECTIVE...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8606836/ https://www.ncbi.nlm.nih.gov/pubmed/34840758 http://dx.doi.org/10.1016/j.amsu.2021.103008 |
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author | Setiawan, Herley Windo Yudhawati, Resti Syafaah, Irmi |
author_facet | Setiawan, Herley Windo Yudhawati, Resti Syafaah, Irmi |
author_sort | Setiawan, Herley Windo |
collection | PubMed |
description | BACKGROUND: Mycobacterium tuberculosis that infected apoptotic macrophages is triggered by PGE(2). Apoptosis suppresses the growth of Mycobacterium tuberculosis bacteria, which is shown in the results of acid-fast bacilli (AFB) in the sputum that becomes a marker of the number of bacteria. OBJECTIVE: Analyzing the association between serum PGE(2) levels and the positivity of AFB in the sputum of tuberculosis patients. METHODS: A cross-sectional study was carried out from August 2019–July 2020. Serum PGE(2) levels and AFB levels in sputum were collected from participants. Data analysis used the Chi-square test and Spearman's correlation with p < 0.05. RESULTS: The average participants’ serum PGE(2) levels were 446.37 ± 510.27 pg/ml, with a median value of 216.95 pg/ml. Most participants had normal serum PGE(2) levels (62.9%). Most participants had a high positivity of AFB in sputum (58.1%). Analysis of the association between serum PGE(2) levels and the degree of AFB positivity in sputum obtained r = −0.036 and p-value = 0.780. CONCLUSION: There is a weak negative association between serum PGE(2) levels and the degree of AFB positivity in sputum but not statistically significant. |
format | Online Article Text |
id | pubmed-8606836 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-86068362021-11-26 Association between serum PGE(2) levels and degree of acid-fast bacilli positivity in sputum of pulmonary tuberculosis patients Setiawan, Herley Windo Yudhawati, Resti Syafaah, Irmi Ann Med Surg (Lond) Cross-sectional Study BACKGROUND: Mycobacterium tuberculosis that infected apoptotic macrophages is triggered by PGE(2). Apoptosis suppresses the growth of Mycobacterium tuberculosis bacteria, which is shown in the results of acid-fast bacilli (AFB) in the sputum that becomes a marker of the number of bacteria. OBJECTIVE: Analyzing the association between serum PGE(2) levels and the positivity of AFB in the sputum of tuberculosis patients. METHODS: A cross-sectional study was carried out from August 2019–July 2020. Serum PGE(2) levels and AFB levels in sputum were collected from participants. Data analysis used the Chi-square test and Spearman's correlation with p < 0.05. RESULTS: The average participants’ serum PGE(2) levels were 446.37 ± 510.27 pg/ml, with a median value of 216.95 pg/ml. Most participants had normal serum PGE(2) levels (62.9%). Most participants had a high positivity of AFB in sputum (58.1%). Analysis of the association between serum PGE(2) levels and the degree of AFB positivity in sputum obtained r = −0.036 and p-value = 0.780. CONCLUSION: There is a weak negative association between serum PGE(2) levels and the degree of AFB positivity in sputum but not statistically significant. Elsevier 2021-11-03 /pmc/articles/PMC8606836/ /pubmed/34840758 http://dx.doi.org/10.1016/j.amsu.2021.103008 Text en © 2021 Published by Elsevier Ltd on behalf of IJS Publishing Group Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Cross-sectional Study Setiawan, Herley Windo Yudhawati, Resti Syafaah, Irmi Association between serum PGE(2) levels and degree of acid-fast bacilli positivity in sputum of pulmonary tuberculosis patients |
title | Association between serum PGE(2) levels and degree of acid-fast bacilli positivity in sputum of pulmonary tuberculosis patients |
title_full | Association between serum PGE(2) levels and degree of acid-fast bacilli positivity in sputum of pulmonary tuberculosis patients |
title_fullStr | Association between serum PGE(2) levels and degree of acid-fast bacilli positivity in sputum of pulmonary tuberculosis patients |
title_full_unstemmed | Association between serum PGE(2) levels and degree of acid-fast bacilli positivity in sputum of pulmonary tuberculosis patients |
title_short | Association between serum PGE(2) levels and degree of acid-fast bacilli positivity in sputum of pulmonary tuberculosis patients |
title_sort | association between serum pge(2) levels and degree of acid-fast bacilli positivity in sputum of pulmonary tuberculosis patients |
topic | Cross-sectional Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8606836/ https://www.ncbi.nlm.nih.gov/pubmed/34840758 http://dx.doi.org/10.1016/j.amsu.2021.103008 |
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