Cargando…

Aberrant Changes in Cortical Complexity in Right-Onset Versus Left-Onset Parkinson’s Disease in Early-Stage

There is increasing evidence to show that motor symptom lateralization in Parkinson’s disease (PD) is linked to non-motor features, progression, and prognosis of the disease. However, few studies have reported the difference in cortical complexity between patients with left-onset of PD (LPD) and rig...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Lin, Shen, Qin, Liao, Haiyan, Li, Junli, Wang, Tianyu, Zi, Yuheng, Zhou, Fan, Song, Chendie, Mao, Zhenni, Wang, Min, Cai, Sainan, Tan, Changlian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8606890/
https://www.ncbi.nlm.nih.gov/pubmed/34819848
http://dx.doi.org/10.3389/fnagi.2021.749606
_version_ 1784602434793897984
author Zhang, Lin
Shen, Qin
Liao, Haiyan
Li, Junli
Wang, Tianyu
Zi, Yuheng
Zhou, Fan
Song, Chendie
Mao, Zhenni
Wang, Min
Cai, Sainan
Tan, Changlian
author_facet Zhang, Lin
Shen, Qin
Liao, Haiyan
Li, Junli
Wang, Tianyu
Zi, Yuheng
Zhou, Fan
Song, Chendie
Mao, Zhenni
Wang, Min
Cai, Sainan
Tan, Changlian
author_sort Zhang, Lin
collection PubMed
description There is increasing evidence to show that motor symptom lateralization in Parkinson’s disease (PD) is linked to non-motor features, progression, and prognosis of the disease. However, few studies have reported the difference in cortical complexity between patients with left-onset of PD (LPD) and right-onset of PD (RPD). This study aimed to investigate the differences in the cortical complexity between early-stage LPD and RPD. High-resolution T1-weighted magnetic resonance images of the brain were acquired in 24 patients with LPD, 34 patients with RPD, and 37 age- and sex-matched healthy controls (HCs). Cortical complexity including gyrification index, fractal dimension (FD), and sulcal depth was analyzed using surface-based morphometry via CAT12/SPM12. Familywise error (FWE) peak-level correction at p < 0.05 was performed for significance testing. In patients with RPD, we found decreased mean FD and mean sulcal depth in the banks of the left superior temporal sulcus (STS) compared with LPD and HCs. The mean FD in the left superior temporal gyrus (STG) was decreased in RPD compared with HCs. However, in patients with LPD, we did not identify significantly abnormal cortical complex change compared with HCs. Moreover, we observed that the mean FD in STG was negatively correlated with the 17-item Hamilton Depression Scale (HAMD) among the three groups. Our findings support the specific influence of asymmetrical motor symptoms in cortical complexity in early-stage PD and reveal that the banks of left STS and left STG might play a crucial role in RPD.
format Online
Article
Text
id pubmed-8606890
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-86068902021-11-23 Aberrant Changes in Cortical Complexity in Right-Onset Versus Left-Onset Parkinson’s Disease in Early-Stage Zhang, Lin Shen, Qin Liao, Haiyan Li, Junli Wang, Tianyu Zi, Yuheng Zhou, Fan Song, Chendie Mao, Zhenni Wang, Min Cai, Sainan Tan, Changlian Front Aging Neurosci Neuroscience There is increasing evidence to show that motor symptom lateralization in Parkinson’s disease (PD) is linked to non-motor features, progression, and prognosis of the disease. However, few studies have reported the difference in cortical complexity between patients with left-onset of PD (LPD) and right-onset of PD (RPD). This study aimed to investigate the differences in the cortical complexity between early-stage LPD and RPD. High-resolution T1-weighted magnetic resonance images of the brain were acquired in 24 patients with LPD, 34 patients with RPD, and 37 age- and sex-matched healthy controls (HCs). Cortical complexity including gyrification index, fractal dimension (FD), and sulcal depth was analyzed using surface-based morphometry via CAT12/SPM12. Familywise error (FWE) peak-level correction at p < 0.05 was performed for significance testing. In patients with RPD, we found decreased mean FD and mean sulcal depth in the banks of the left superior temporal sulcus (STS) compared with LPD and HCs. The mean FD in the left superior temporal gyrus (STG) was decreased in RPD compared with HCs. However, in patients with LPD, we did not identify significantly abnormal cortical complex change compared with HCs. Moreover, we observed that the mean FD in STG was negatively correlated with the 17-item Hamilton Depression Scale (HAMD) among the three groups. Our findings support the specific influence of asymmetrical motor symptoms in cortical complexity in early-stage PD and reveal that the banks of left STS and left STG might play a crucial role in RPD. Frontiers Media S.A. 2021-11-08 /pmc/articles/PMC8606890/ /pubmed/34819848 http://dx.doi.org/10.3389/fnagi.2021.749606 Text en Copyright © 2021 Zhang, Shen, Liao, Li, Wang, Zi, Zhou, Song, Mao, Wang, Cai and Tan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Zhang, Lin
Shen, Qin
Liao, Haiyan
Li, Junli
Wang, Tianyu
Zi, Yuheng
Zhou, Fan
Song, Chendie
Mao, Zhenni
Wang, Min
Cai, Sainan
Tan, Changlian
Aberrant Changes in Cortical Complexity in Right-Onset Versus Left-Onset Parkinson’s Disease in Early-Stage
title Aberrant Changes in Cortical Complexity in Right-Onset Versus Left-Onset Parkinson’s Disease in Early-Stage
title_full Aberrant Changes in Cortical Complexity in Right-Onset Versus Left-Onset Parkinson’s Disease in Early-Stage
title_fullStr Aberrant Changes in Cortical Complexity in Right-Onset Versus Left-Onset Parkinson’s Disease in Early-Stage
title_full_unstemmed Aberrant Changes in Cortical Complexity in Right-Onset Versus Left-Onset Parkinson’s Disease in Early-Stage
title_short Aberrant Changes in Cortical Complexity in Right-Onset Versus Left-Onset Parkinson’s Disease in Early-Stage
title_sort aberrant changes in cortical complexity in right-onset versus left-onset parkinson’s disease in early-stage
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8606890/
https://www.ncbi.nlm.nih.gov/pubmed/34819848
http://dx.doi.org/10.3389/fnagi.2021.749606
work_keys_str_mv AT zhanglin aberrantchangesincorticalcomplexityinrightonsetversusleftonsetparkinsonsdiseaseinearlystage
AT shenqin aberrantchangesincorticalcomplexityinrightonsetversusleftonsetparkinsonsdiseaseinearlystage
AT liaohaiyan aberrantchangesincorticalcomplexityinrightonsetversusleftonsetparkinsonsdiseaseinearlystage
AT lijunli aberrantchangesincorticalcomplexityinrightonsetversusleftonsetparkinsonsdiseaseinearlystage
AT wangtianyu aberrantchangesincorticalcomplexityinrightonsetversusleftonsetparkinsonsdiseaseinearlystage
AT ziyuheng aberrantchangesincorticalcomplexityinrightonsetversusleftonsetparkinsonsdiseaseinearlystage
AT zhoufan aberrantchangesincorticalcomplexityinrightonsetversusleftonsetparkinsonsdiseaseinearlystage
AT songchendie aberrantchangesincorticalcomplexityinrightonsetversusleftonsetparkinsonsdiseaseinearlystage
AT maozhenni aberrantchangesincorticalcomplexityinrightonsetversusleftonsetparkinsonsdiseaseinearlystage
AT wangmin aberrantchangesincorticalcomplexityinrightonsetversusleftonsetparkinsonsdiseaseinearlystage
AT caisainan aberrantchangesincorticalcomplexityinrightonsetversusleftonsetparkinsonsdiseaseinearlystage
AT tanchanglian aberrantchangesincorticalcomplexityinrightonsetversusleftonsetparkinsonsdiseaseinearlystage