Deletion of pancreas-specific miR-216a reduces beta-cell mass and inhibits pancreatic cancer progression in mice

miRNAs have crucial functions in many biological processes and are candidate biomarkers of disease. Here, we show that miR-216a is a conserved, pancreas-specific miRNA with important roles in pancreatic islet and acinar cells. Deletion of miR-216a in mice leads to a reduction in islet size, β-cell m...

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Detalles Bibliográficos
Autores principales: Erener, Suheda, Ellis, Cara E., Ramzy, Adam, Glavas, Maria M., O’Dwyer, Shannon, Pereira, Sandra, Wang, Tom, Pang, Janice, Bruin, Jennifer E., Riedel, Michael J., Baker, Robert K., Webber, Travis D., Lesina, Marina, Blüher, Matthias, Algül, Hana, Kopp, Janel L., Herzig, Stephan, Kieffer, Timothy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8606901/
https://www.ncbi.nlm.nih.gov/pubmed/34841287
http://dx.doi.org/10.1016/j.xcrm.2021.100434

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