Vaccine targeting ANGPTL3 ameliorates dyslipidemia and associated diseases in mouse models of obese dyslipidemia and familial hypercholesterolemia

Dyslipidemia is a risk factor for cardiovascular disease (CVD), a major cause of death worldwide. Angiopoietin-like protein 3 (ANGPTL3), recognized as a new therapeutic target for dyslipidemia, regulates the metabolism of low-density lipoprotein-cholesterol (LDL-C) and triglycerides. Here, we design...

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Detalles Bibliográficos
Autores principales: Fukami, Hirotaka, Morinaga, Jun, Nakagami, Hironori, Hayashi, Hiroki, Okadome, Yusuke, Matsunaga, Eiji, Kadomatsu, Tsuyoshi, Horiguchi, Haruki, Sato, Michio, Sugizaki, Taichi, Kuwabara, Takashige, Miyata, Keishi, Mukoyama, Masashi, Morishita, Ryuichi, Oike, Yuichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8606905/
https://www.ncbi.nlm.nih.gov/pubmed/34841293
http://dx.doi.org/10.1016/j.xcrm.2021.100446

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