Is there a familial predisposition to bisphosphonate-induced atypical femoral fractures?

Bisphosphonates are commonly used in the treatment of osteoporosis. Atypical femoral fracture (AFF) is a well-known adverse effect of bisphosphonate use. The importance of genetic factors has been demonstrated in bone quality, bone turnover, and in the response to osteoporosis treatment. Herein, we...

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Autores principales: Okçu, Mehmet, Aybala Koçak, Fatmanur, Sancar Kaya, Samet, Tuncay, Figen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bayçınar Medical Publishing 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8606994/
https://www.ncbi.nlm.nih.gov/pubmed/34870126
http://dx.doi.org/10.5606/tftrd.2021.5248
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author Okçu, Mehmet
Aybala Koçak, Fatmanur
Sancar Kaya, Samet
Tuncay, Figen
author_facet Okçu, Mehmet
Aybala Koçak, Fatmanur
Sancar Kaya, Samet
Tuncay, Figen
author_sort Okçu, Mehmet
collection PubMed
description Bisphosphonates are commonly used in the treatment of osteoporosis. Atypical femoral fracture (AFF) is a well-known adverse effect of bisphosphonate use. The importance of genetic factors has been demonstrated in bone quality, bone turnover, and in the response to osteoporosis treatment. Herein, we present two cases of bilateral AFFs after bisphosphonate use for a short period of time in members of the same family (mother and her daughter) and discuss genetic predisposition to bisphosphonate-induced AFFs in the light of literature data.
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spelling pubmed-86069942021-12-02 Is there a familial predisposition to bisphosphonate-induced atypical femoral fractures? Okçu, Mehmet Aybala Koçak, Fatmanur Sancar Kaya, Samet Tuncay, Figen Turk J Phys Med Rehabil Case Report Bisphosphonates are commonly used in the treatment of osteoporosis. Atypical femoral fracture (AFF) is a well-known adverse effect of bisphosphonate use. The importance of genetic factors has been demonstrated in bone quality, bone turnover, and in the response to osteoporosis treatment. Herein, we present two cases of bilateral AFFs after bisphosphonate use for a short period of time in members of the same family (mother and her daughter) and discuss genetic predisposition to bisphosphonate-induced AFFs in the light of literature data. Bayçınar Medical Publishing 2021-09-01 /pmc/articles/PMC8606994/ /pubmed/34870126 http://dx.doi.org/10.5606/tftrd.2021.5248 Text en Copyright © 2021, Turkish Society of Physical Medicine and Rehabilitation https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Case Report
Okçu, Mehmet
Aybala Koçak, Fatmanur
Sancar Kaya, Samet
Tuncay, Figen
Is there a familial predisposition to bisphosphonate-induced atypical femoral fractures?
title Is there a familial predisposition to bisphosphonate-induced atypical femoral fractures?
title_full Is there a familial predisposition to bisphosphonate-induced atypical femoral fractures?
title_fullStr Is there a familial predisposition to bisphosphonate-induced atypical femoral fractures?
title_full_unstemmed Is there a familial predisposition to bisphosphonate-induced atypical femoral fractures?
title_short Is there a familial predisposition to bisphosphonate-induced atypical femoral fractures?
title_sort is there a familial predisposition to bisphosphonate-induced atypical femoral fractures?
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8606994/
https://www.ncbi.nlm.nih.gov/pubmed/34870126
http://dx.doi.org/10.5606/tftrd.2021.5248
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