伴MLL-AF9基因重排和肝功能损伤的急性髓系白血病自发缓解一例报告并文献复习

OBJECTIVE: To explore the clinical features and possible pathogenesis of spontaneous remission of acute myeloid leukemia (AML). METHODS: We retrospectively analyzed the clinical data of a patient with spontaneous remission of AML, MLL-AF9 rearrangement, and abnormal liver function in the First Affiliated Hospital of Zhengzhou University, and the relevant pieces of literature were summarized. RESULTS: The patient experienced lung infection, fever, and liver dysfunction and was treated with anti-infection and blood transfusion. After complete response (CR), the patient remained in CR with mild, indirect bilirubin elevation at 35 months of follow-up. Additionally, 56 cases of adult AML (non-acute promyelocytic leukemia) were reported in the literature from 1990 to June 2021. The cases were checked by bone marrow aspiration, and our patients were summarized and analyzed. Furthermore, 57 patients, including 37 males and 20 females, with a median age of 51 (20–83) years and a median remission time of five months; 52 patients achieved complete remission. In addition, there were five cases with long-term remission and a chromosomal record, with no recurrence so far, three with normal karyotype and two with t(9;11) (q21;q23). CONCLUSION: The spontaneous remission of leukemia is rare and may be related to immunosuppression and genes.