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Antioxidant support to ameliorate the oxaliplatin-dependent microglial alteration: Morphological and molecular study
Oxaliplatin is a third-generation chemotherapy drug mainly used for colorectal cancer treatment. However, it is also known to trigger neuropathy whose underlying neurobiological mechanisms are still under investigation and currently available treatments show limited efficacy. It is now established t...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PAGEPress Publications, Pavia, Italy
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8607276/ https://www.ncbi.nlm.nih.gov/pubmed/34755507 http://dx.doi.org/10.4081/ejh.2021.3285 |
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author | Branca, Jacopo J.V. Carrino, Donatello Paternostro, Ferdinando Gulisano, Massimo Becatti, Matteo Di Cesare Mannelli, Lorenzo Pacini, Alessandra |
author_facet | Branca, Jacopo J.V. Carrino, Donatello Paternostro, Ferdinando Gulisano, Massimo Becatti, Matteo Di Cesare Mannelli, Lorenzo Pacini, Alessandra |
author_sort | Branca, Jacopo J.V. |
collection | PubMed |
description | Oxaliplatin is a third-generation chemotherapy drug mainly used for colorectal cancer treatment. However, it is also known to trigger neuropathy whose underlying neurobiological mechanisms are still under investigation and currently available treatments show limited efficacy. It is now established that neurons are not the only cell type involved in chronic pain and that glial cells, mainly microglia and astrocytes, are implicated in the initiation and maintenance of neuropathy. Among all the pathogenetic factors involved in neuropathic pain, an oxaliplatin- dependent oxidative stress plays a predominant role. In our study, the antioxidant properties of magnesium (Mg), manganese (Mn) and zinc (Zn) salts were evaluated in order to counteract microglial activation induced by oxaliplatin. The antioxidant efficacy of these metals was evaluated by means of molecular and morphological assays on the BV-2 microglial cell line. Our data clearly show that Mg, Mn and Zn salts are able to prevent oxaliplatin-dependent microglial alterations by reducing both oxidative and endoplasmic reticulum stress. |
format | Online Article Text |
id | pubmed-8607276 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | PAGEPress Publications, Pavia, Italy |
record_format | MEDLINE/PubMed |
spelling | pubmed-86072762021-12-09 Antioxidant support to ameliorate the oxaliplatin-dependent microglial alteration: Morphological and molecular study Branca, Jacopo J.V. Carrino, Donatello Paternostro, Ferdinando Gulisano, Massimo Becatti, Matteo Di Cesare Mannelli, Lorenzo Pacini, Alessandra Eur J Histochem Brief Report Oxaliplatin is a third-generation chemotherapy drug mainly used for colorectal cancer treatment. However, it is also known to trigger neuropathy whose underlying neurobiological mechanisms are still under investigation and currently available treatments show limited efficacy. It is now established that neurons are not the only cell type involved in chronic pain and that glial cells, mainly microglia and astrocytes, are implicated in the initiation and maintenance of neuropathy. Among all the pathogenetic factors involved in neuropathic pain, an oxaliplatin- dependent oxidative stress plays a predominant role. In our study, the antioxidant properties of magnesium (Mg), manganese (Mn) and zinc (Zn) salts were evaluated in order to counteract microglial activation induced by oxaliplatin. The antioxidant efficacy of these metals was evaluated by means of molecular and morphological assays on the BV-2 microglial cell line. Our data clearly show that Mg, Mn and Zn salts are able to prevent oxaliplatin-dependent microglial alterations by reducing both oxidative and endoplasmic reticulum stress. PAGEPress Publications, Pavia, Italy 2021-11-10 /pmc/articles/PMC8607276/ /pubmed/34755507 http://dx.doi.org/10.4081/ejh.2021.3285 Text en ©Copyright: the Author(s) https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Brief Report Branca, Jacopo J.V. Carrino, Donatello Paternostro, Ferdinando Gulisano, Massimo Becatti, Matteo Di Cesare Mannelli, Lorenzo Pacini, Alessandra Antioxidant support to ameliorate the oxaliplatin-dependent microglial alteration: Morphological and molecular study |
title | Antioxidant support to ameliorate the oxaliplatin-dependent microglial alteration: Morphological and molecular study |
title_full | Antioxidant support to ameliorate the oxaliplatin-dependent microglial alteration: Morphological and molecular study |
title_fullStr | Antioxidant support to ameliorate the oxaliplatin-dependent microglial alteration: Morphological and molecular study |
title_full_unstemmed | Antioxidant support to ameliorate the oxaliplatin-dependent microglial alteration: Morphological and molecular study |
title_short | Antioxidant support to ameliorate the oxaliplatin-dependent microglial alteration: Morphological and molecular study |
title_sort | antioxidant support to ameliorate the oxaliplatin-dependent microglial alteration: morphological and molecular study |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8607276/ https://www.ncbi.nlm.nih.gov/pubmed/34755507 http://dx.doi.org/10.4081/ejh.2021.3285 |
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