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小细胞肺癌合并腺癌MDT治疗报道及文献综述
Small cell lung cancer (SCLC) is the most malignant lung cancer with the highest mortality. At present, the first-line standard treatment is still based on Etoposide and Platinum chemotherapy. However, for SCLC that progresses after first-line therapy, the treatment options are still very limited. S...
Formato: | Online Artículo Texto |
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Lenguaje: | English |
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中国肺癌杂志编辑部
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8607282/ https://www.ncbi.nlm.nih.gov/pubmed/34802214 http://dx.doi.org/10.3779/j.issn.1009-3419.2021.102.37 |
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collection | PubMed |
description | Small cell lung cancer (SCLC) is the most malignant lung cancer with the highest mortality. At present, the first-line standard treatment is still based on Etoposide and Platinum chemotherapy. However, for SCLC that progresses after first-line therapy, the treatment options are still very limited. Since the molecular mechanism of first-line drug resistance of SCLC is still unclear, and the precision medicine strategy after first-line drug resistance is still in the pre-clinical stage. The proportion of secondary biopsy and genetic testing is very low after the progress of first-line treatment of SCLC. In this study, we report a case of a middle-aged woman who was first diagnosed with SCLC. Adenocarcinoma with sensitive gene mutations and repeated changes of small cell carcinoma were detected by multiple biopsies during the course of the disease, suggesting that the patient may be a special subtype of SCLC - mixed SCLC (M-SCLC). In this case, the patient has been treated with radiotherapy and chemotherapy, immunotherapy and targeted therapy successively, and the survival time has reached 2 years and 8 months. Through the case report and literature review retrospectively, this study aimed to explore the part patients may start to present hybrid histopathologic types or tissue type change after treatment of SCLC. Biopsy pathologic histology and genetic testing is necessary after disease progression to look for potential therapeutic targets, so as to give precise treatment based on molecular markers detection results and provide the patient with the benefit of survival for as long as possible. |
format | Online Article Text |
id | pubmed-8607282 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | 中国肺癌杂志编辑部 |
record_format | MEDLINE/PubMed |
spelling | pubmed-86072822021-12-03 小细胞肺癌合并腺癌MDT治疗报道及文献综述 Zhongguo Fei Ai Za Zhi 病例报道 Small cell lung cancer (SCLC) is the most malignant lung cancer with the highest mortality. At present, the first-line standard treatment is still based on Etoposide and Platinum chemotherapy. However, for SCLC that progresses after first-line therapy, the treatment options are still very limited. Since the molecular mechanism of first-line drug resistance of SCLC is still unclear, and the precision medicine strategy after first-line drug resistance is still in the pre-clinical stage. The proportion of secondary biopsy and genetic testing is very low after the progress of first-line treatment of SCLC. In this study, we report a case of a middle-aged woman who was first diagnosed with SCLC. Adenocarcinoma with sensitive gene mutations and repeated changes of small cell carcinoma were detected by multiple biopsies during the course of the disease, suggesting that the patient may be a special subtype of SCLC - mixed SCLC (M-SCLC). In this case, the patient has been treated with radiotherapy and chemotherapy, immunotherapy and targeted therapy successively, and the survival time has reached 2 years and 8 months. Through the case report and literature review retrospectively, this study aimed to explore the part patients may start to present hybrid histopathologic types or tissue type change after treatment of SCLC. Biopsy pathologic histology and genetic testing is necessary after disease progression to look for potential therapeutic targets, so as to give precise treatment based on molecular markers detection results and provide the patient with the benefit of survival for as long as possible. 中国肺癌杂志编辑部 2021-11-20 /pmc/articles/PMC8607282/ /pubmed/34802214 http://dx.doi.org/10.3779/j.issn.1009-3419.2021.102.37 Text en 版权所有©《中国肺癌杂志》编辑部2021 https://creativecommons.org/licenses/by/3.0/This is an open access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 3.0) License. See: https://creativecommons.org/licenses/by/3.0/. |
spellingShingle | 病例报道 小细胞肺癌合并腺癌MDT治疗报道及文献综述 |
title | 小细胞肺癌合并腺癌MDT治疗报道及文献综述 |
title_full | 小细胞肺癌合并腺癌MDT治疗报道及文献综述 |
title_fullStr | 小细胞肺癌合并腺癌MDT治疗报道及文献综述 |
title_full_unstemmed | 小细胞肺癌合并腺癌MDT治疗报道及文献综述 |
title_short | 小细胞肺癌合并腺癌MDT治疗报道及文献综述 |
title_sort | 小细胞肺癌合并腺癌mdt治疗报道及文献综述 |
topic | 病例报道 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8607282/ https://www.ncbi.nlm.nih.gov/pubmed/34802214 http://dx.doi.org/10.3779/j.issn.1009-3419.2021.102.37 |
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