Synthesis and evaluation of squaramide and thiosquaramide inhibitors of the DNA repair enzyme SNM1A

SNM1A is a zinc-dependent nuclease involved in the removal of interstrand crosslink lesions from DNA. Inhibition of interstrand crosslink repair enzymes such as SNM1A is a promising strategy for improving the efficacy of crosslinking chemotherapy drugs. Initial studies have demonstrated the feasibil...

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Detalles Bibliográficos
Autores principales: Berney, Mark, Doherty, William, Jauslin, Werner Theodor, T Manoj, Manav, Dürr, Eva-Maria, McGouran, Joanna Francelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8607331/
https://www.ncbi.nlm.nih.gov/pubmed/34482229
http://dx.doi.org/10.1016/j.bmc.2021.116369

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8607331/
https://www.ncbi.nlm.nih.gov/pubmed/34482229
http://dx.doi.org/10.1016/j.bmc.2021.116369

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