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Synthesis and evaluation of squaramide and thiosquaramide inhibitors of the DNA repair enzyme SNM1A
SNM1A is a zinc-dependent nuclease involved in the removal of interstrand crosslink lesions from DNA. Inhibition of interstrand crosslink repair enzymes such as SNM1A is a promising strategy for improving the efficacy of crosslinking chemotherapy drugs. Initial studies have demonstrated the feasibil...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Science
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8607331/ https://www.ncbi.nlm.nih.gov/pubmed/34482229 http://dx.doi.org/10.1016/j.bmc.2021.116369 |