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Expressions and significances of CTSL, the target of COVID‐19 on GBM

INTRODUCTION: Cathepsin L (CTSL) is a kind of the SARS-entry-associated CoV-2's proteases, which plays a key role in the virus's entry into the cell and subsequent infection. We investigated the association between the expression level of CTSL and overall survival in Glioblastoma multiform...

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Autores principales: Dong, Qiang, Li, Qiao, Duan, Lei, Wang, Hongyu, Yan, Yunji, Yin, Hang, Niu, Liang, Zhang, He, wang, Bo, Yuan, Guoqiang, Pan, Yawen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8607410/
https://www.ncbi.nlm.nih.gov/pubmed/34807310
http://dx.doi.org/10.1007/s00432-021-03843-9
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author Dong, Qiang
Li, Qiao
Duan, Lei
Wang, Hongyu
Yan, Yunji
Yin, Hang
Niu, Liang
Zhang, He
wang, Bo
Yuan, Guoqiang
Pan, Yawen
author_facet Dong, Qiang
Li, Qiao
Duan, Lei
Wang, Hongyu
Yan, Yunji
Yin, Hang
Niu, Liang
Zhang, He
wang, Bo
Yuan, Guoqiang
Pan, Yawen
author_sort Dong, Qiang
collection PubMed
description INTRODUCTION: Cathepsin L (CTSL) is a kind of the SARS-entry-associated CoV-2's proteases, which plays a key role in the virus's entry into the cell and subsequent infection. We investigated the association between the expression level of CTSL and overall survival in Glioblastoma multiforme (GBM) patients, to better understand the possible route and risks of new coronavirus infection for patients with GBM. METHODS: The expression level of CTSL in GBM was analyzed using TCGA and CGGA databases. The relationship between CTSL and immune infiltration levels was analyzed by means of the TIMER database. The impact of CTSL inhibitors on GBM biological activity was tested. RESULTS: The findings revealed that GBM tissues had higher CTSL expression levels than that of normal brain tissues, which was associated with a significantly lower survival rate in GBM patients. Meanwhile, the expression level of CTSL negatively correlated with purity, B cell and CD8(+) T cell in GBM. CTSL inhibitor significantly reduced growth and induced mitochondrial apoptosis. CONCLUSION: According to the findings, CTSL acts as an independent prognostic factor and can be considered as promising therapeutic target for GBM. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00432-021-03843-9.
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spelling pubmed-86074102021-11-22 Expressions and significances of CTSL, the target of COVID‐19 on GBM Dong, Qiang Li, Qiao Duan, Lei Wang, Hongyu Yan, Yunji Yin, Hang Niu, Liang Zhang, He wang, Bo Yuan, Guoqiang Pan, Yawen J Cancer Res Clin Oncol Original Article – Cancer Research INTRODUCTION: Cathepsin L (CTSL) is a kind of the SARS-entry-associated CoV-2's proteases, which plays a key role in the virus's entry into the cell and subsequent infection. We investigated the association between the expression level of CTSL and overall survival in Glioblastoma multiforme (GBM) patients, to better understand the possible route and risks of new coronavirus infection for patients with GBM. METHODS: The expression level of CTSL in GBM was analyzed using TCGA and CGGA databases. The relationship between CTSL and immune infiltration levels was analyzed by means of the TIMER database. The impact of CTSL inhibitors on GBM biological activity was tested. RESULTS: The findings revealed that GBM tissues had higher CTSL expression levels than that of normal brain tissues, which was associated with a significantly lower survival rate in GBM patients. Meanwhile, the expression level of CTSL negatively correlated with purity, B cell and CD8(+) T cell in GBM. CTSL inhibitor significantly reduced growth and induced mitochondrial apoptosis. CONCLUSION: According to the findings, CTSL acts as an independent prognostic factor and can be considered as promising therapeutic target for GBM. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00432-021-03843-9. Springer Berlin Heidelberg 2021-11-22 2022 /pmc/articles/PMC8607410/ /pubmed/34807310 http://dx.doi.org/10.1007/s00432-021-03843-9 Text en © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Original Article – Cancer Research
Dong, Qiang
Li, Qiao
Duan, Lei
Wang, Hongyu
Yan, Yunji
Yin, Hang
Niu, Liang
Zhang, He
wang, Bo
Yuan, Guoqiang
Pan, Yawen
Expressions and significances of CTSL, the target of COVID‐19 on GBM
title Expressions and significances of CTSL, the target of COVID‐19 on GBM
title_full Expressions and significances of CTSL, the target of COVID‐19 on GBM
title_fullStr Expressions and significances of CTSL, the target of COVID‐19 on GBM
title_full_unstemmed Expressions and significances of CTSL, the target of COVID‐19 on GBM
title_short Expressions and significances of CTSL, the target of COVID‐19 on GBM
title_sort expressions and significances of ctsl, the target of covid‐19 on gbm
topic Original Article – Cancer Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8607410/
https://www.ncbi.nlm.nih.gov/pubmed/34807310
http://dx.doi.org/10.1007/s00432-021-03843-9
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