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Lack of progression of beta dynamics after long‐term subthalamic neurostimulation

OBJECTIVE: To investigate the progression of neural and motor features of Parkinson's disease in a longitudinal study, after washout of medication and bilateral subthalamic nucleus deep brain stimulation (STN DBS). METHODS: Participants with clinically established Parkinson's disease under...

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Autores principales: Anderson, Ross W., Wilkins, Kevin B., Parker, Jordan E., Petrucci, Matthew N., Kehnemouyi, Yasmine, Neuville, Raumin S., Cassini, Declan, Trager, Megan H., Koop, Mandy M., Velisar, Anca, Blumenfeld, Zack, Quinn, Emma J., Henderson, Jaimie, Bronte‐Stewart, Helen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8607445/
https://www.ncbi.nlm.nih.gov/pubmed/34636182
http://dx.doi.org/10.1002/acn3.51463
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author Anderson, Ross W.
Wilkins, Kevin B.
Parker, Jordan E.
Petrucci, Matthew N.
Kehnemouyi, Yasmine
Neuville, Raumin S.
Cassini, Declan
Trager, Megan H.
Koop, Mandy M.
Velisar, Anca
Blumenfeld, Zack
Quinn, Emma J.
Henderson, Jaimie
Bronte‐Stewart, Helen M.
author_facet Anderson, Ross W.
Wilkins, Kevin B.
Parker, Jordan E.
Petrucci, Matthew N.
Kehnemouyi, Yasmine
Neuville, Raumin S.
Cassini, Declan
Trager, Megan H.
Koop, Mandy M.
Velisar, Anca
Blumenfeld, Zack
Quinn, Emma J.
Henderson, Jaimie
Bronte‐Stewart, Helen M.
author_sort Anderson, Ross W.
collection PubMed
description OBJECTIVE: To investigate the progression of neural and motor features of Parkinson's disease in a longitudinal study, after washout of medication and bilateral subthalamic nucleus deep brain stimulation (STN DBS). METHODS: Participants with clinically established Parkinson's disease underwent bilateral implantation of DBS leads (18 participants, 13 male) within the STN using standard functional frameless stereotactic technique and multi‐pass microelectrode recording. Both DBS leads were connected to an implanted investigative sensing neurostimulator (Activa™ PC + S, Medtronic, PLC). Resting state STN local field potentials (LFPs) were recorded and motor disability, (the Movement Disorder Society‐Unified Parkinson's Disease Rating Scale – motor subscale, MDS‐UPDRS III) was assessed off therapy at initial programming, and after 6 months, 1 year, and yearly out to 5 years of treatment. The primary endpoint was measured at 3 years. At each visit, medication had been held for over 12/24 h and DBS was turned off for at least 60 min, by which time LFP spectra reached a steady state. RESULTS: After 3 years of chronic DBS, there were no increases in STN beta band dynamics (p = 0.98) but there were increases in alpha band dynamics (p = 0.0027, 25 STNs). Similar results were observed in a smaller cohort out to 5 years. There was no increase in the MDS‐UPDRS III score. INTERPRETATION: These findings provide evidence that the beta oscillopathy does not substantially progress following combined STN DBS plus medication in moderate to advanced Parkinson's disease.
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spelling pubmed-86074452021-11-29 Lack of progression of beta dynamics after long‐term subthalamic neurostimulation Anderson, Ross W. Wilkins, Kevin B. Parker, Jordan E. Petrucci, Matthew N. Kehnemouyi, Yasmine Neuville, Raumin S. Cassini, Declan Trager, Megan H. Koop, Mandy M. Velisar, Anca Blumenfeld, Zack Quinn, Emma J. Henderson, Jaimie Bronte‐Stewart, Helen M. Ann Clin Transl Neurol Research Articles OBJECTIVE: To investigate the progression of neural and motor features of Parkinson's disease in a longitudinal study, after washout of medication and bilateral subthalamic nucleus deep brain stimulation (STN DBS). METHODS: Participants with clinically established Parkinson's disease underwent bilateral implantation of DBS leads (18 participants, 13 male) within the STN using standard functional frameless stereotactic technique and multi‐pass microelectrode recording. Both DBS leads were connected to an implanted investigative sensing neurostimulator (Activa™ PC + S, Medtronic, PLC). Resting state STN local field potentials (LFPs) were recorded and motor disability, (the Movement Disorder Society‐Unified Parkinson's Disease Rating Scale – motor subscale, MDS‐UPDRS III) was assessed off therapy at initial programming, and after 6 months, 1 year, and yearly out to 5 years of treatment. The primary endpoint was measured at 3 years. At each visit, medication had been held for over 12/24 h and DBS was turned off for at least 60 min, by which time LFP spectra reached a steady state. RESULTS: After 3 years of chronic DBS, there were no increases in STN beta band dynamics (p = 0.98) but there were increases in alpha band dynamics (p = 0.0027, 25 STNs). Similar results were observed in a smaller cohort out to 5 years. There was no increase in the MDS‐UPDRS III score. INTERPRETATION: These findings provide evidence that the beta oscillopathy does not substantially progress following combined STN DBS plus medication in moderate to advanced Parkinson's disease. John Wiley and Sons Inc. 2021-10-11 /pmc/articles/PMC8607445/ /pubmed/34636182 http://dx.doi.org/10.1002/acn3.51463 Text en © 2021 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Anderson, Ross W.
Wilkins, Kevin B.
Parker, Jordan E.
Petrucci, Matthew N.
Kehnemouyi, Yasmine
Neuville, Raumin S.
Cassini, Declan
Trager, Megan H.
Koop, Mandy M.
Velisar, Anca
Blumenfeld, Zack
Quinn, Emma J.
Henderson, Jaimie
Bronte‐Stewart, Helen M.
Lack of progression of beta dynamics after long‐term subthalamic neurostimulation
title Lack of progression of beta dynamics after long‐term subthalamic neurostimulation
title_full Lack of progression of beta dynamics after long‐term subthalamic neurostimulation
title_fullStr Lack of progression of beta dynamics after long‐term subthalamic neurostimulation
title_full_unstemmed Lack of progression of beta dynamics after long‐term subthalamic neurostimulation
title_short Lack of progression of beta dynamics after long‐term subthalamic neurostimulation
title_sort lack of progression of beta dynamics after long‐term subthalamic neurostimulation
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8607445/
https://www.ncbi.nlm.nih.gov/pubmed/34636182
http://dx.doi.org/10.1002/acn3.51463
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