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Determinants of quality of life in Parkinson’s disease: a perspective of novel clinical subtypes
OBJECTIVE: New subtyping classification systems of Parkinson’s disease (PD) have been proposed for phenotyping patients into three different subtypes: mild motor‐predominant (PD‐MMP), intermediate (PD‐IM) and diffuse malignant (PD‐DM). The quality of life (QoL) underlying the novel PD clinical subty...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8607447/ https://www.ncbi.nlm.nih.gov/pubmed/34716746 http://dx.doi.org/10.1002/acn3.51475 |
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author | Fan, Yun Zhang, Mengwei Liang, Xiaoniu Shen, Bo Xu, Zhiheng Li, Shiyu Hu, Tianyu Wu, Bin Zhao, Jue Sun, Yimin Liu, Fengtao Tang, Yilin Wang, Jian |
author_facet | Fan, Yun Zhang, Mengwei Liang, Xiaoniu Shen, Bo Xu, Zhiheng Li, Shiyu Hu, Tianyu Wu, Bin Zhao, Jue Sun, Yimin Liu, Fengtao Tang, Yilin Wang, Jian |
author_sort | Fan, Yun |
collection | PubMed |
description | OBJECTIVE: New subtyping classification systems of Parkinson’s disease (PD) have been proposed for phenotyping patients into three different subtypes: mild motor‐predominant (PD‐MMP), intermediate (PD‐IM) and diffuse malignant (PD‐DM). The quality of life (QoL) underlying the novel PD clinical subtypes is unknown. This study aimed explore the feasibility of the classification in Chinese PD patients and to investigate the potential heterogeneous determinants of QoL among the three subtypes. METHODS: 298 PD patients were enrolled, including 129 PD‐MMP patients, 121 PD‐IM patients and 48 PD‐DM patients. All patients completed the QoL assessment, clinical evaluations and neuropsychological tests. Univariate linear analysis and multiple stepwise regression analysis were performed to identify determinants of QoL. RESULTS: Compared to PD‐MMP patients, PD‐IM and PD‐DM patients had more impaired QoL. The Geriatric Depression Rating Scale (GDS) score, Non‐Motor Symptoms Questionnaire (NMSQ) score, Unified Parkinson’s Disease Rating Scale part III (UPDRS‐III) score and Epworth Sleepiness Score (ESS) were independent contributors to QoL in PD‐MMP patients. The GDS score, ESS and sniffin’ sticks screening 12 test score were independent contributors to QoL in PD‐IM patients. The GDS score and Mini Mental State Examination score were independent contributors to QoL in PD‐DM patients. INTERPRETATION: The new novel subtyping classification is feasible for Chinese PD patients. Although depression was the most crucial determinant for QoL in PD‐MMP, PD‐IM and PD‐DM patients, the other contributors of QoL in the three subtypes were heterogeneous. These findings may prompt clinicians to target specific factors for improving QoL depending on PD subtypes. |
format | Online Article Text |
id | pubmed-8607447 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86074472021-11-29 Determinants of quality of life in Parkinson’s disease: a perspective of novel clinical subtypes Fan, Yun Zhang, Mengwei Liang, Xiaoniu Shen, Bo Xu, Zhiheng Li, Shiyu Hu, Tianyu Wu, Bin Zhao, Jue Sun, Yimin Liu, Fengtao Tang, Yilin Wang, Jian Ann Clin Transl Neurol Research Articles OBJECTIVE: New subtyping classification systems of Parkinson’s disease (PD) have been proposed for phenotyping patients into three different subtypes: mild motor‐predominant (PD‐MMP), intermediate (PD‐IM) and diffuse malignant (PD‐DM). The quality of life (QoL) underlying the novel PD clinical subtypes is unknown. This study aimed explore the feasibility of the classification in Chinese PD patients and to investigate the potential heterogeneous determinants of QoL among the three subtypes. METHODS: 298 PD patients were enrolled, including 129 PD‐MMP patients, 121 PD‐IM patients and 48 PD‐DM patients. All patients completed the QoL assessment, clinical evaluations and neuropsychological tests. Univariate linear analysis and multiple stepwise regression analysis were performed to identify determinants of QoL. RESULTS: Compared to PD‐MMP patients, PD‐IM and PD‐DM patients had more impaired QoL. The Geriatric Depression Rating Scale (GDS) score, Non‐Motor Symptoms Questionnaire (NMSQ) score, Unified Parkinson’s Disease Rating Scale part III (UPDRS‐III) score and Epworth Sleepiness Score (ESS) were independent contributors to QoL in PD‐MMP patients. The GDS score, ESS and sniffin’ sticks screening 12 test score were independent contributors to QoL in PD‐IM patients. The GDS score and Mini Mental State Examination score were independent contributors to QoL in PD‐DM patients. INTERPRETATION: The new novel subtyping classification is feasible for Chinese PD patients. Although depression was the most crucial determinant for QoL in PD‐MMP, PD‐IM and PD‐DM patients, the other contributors of QoL in the three subtypes were heterogeneous. These findings may prompt clinicians to target specific factors for improving QoL depending on PD subtypes. John Wiley and Sons Inc. 2021-10-30 /pmc/articles/PMC8607447/ /pubmed/34716746 http://dx.doi.org/10.1002/acn3.51475 Text en © 2021 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Research Articles Fan, Yun Zhang, Mengwei Liang, Xiaoniu Shen, Bo Xu, Zhiheng Li, Shiyu Hu, Tianyu Wu, Bin Zhao, Jue Sun, Yimin Liu, Fengtao Tang, Yilin Wang, Jian Determinants of quality of life in Parkinson’s disease: a perspective of novel clinical subtypes |
title | Determinants of quality of life in Parkinson’s disease: a perspective of novel clinical subtypes |
title_full | Determinants of quality of life in Parkinson’s disease: a perspective of novel clinical subtypes |
title_fullStr | Determinants of quality of life in Parkinson’s disease: a perspective of novel clinical subtypes |
title_full_unstemmed | Determinants of quality of life in Parkinson’s disease: a perspective of novel clinical subtypes |
title_short | Determinants of quality of life in Parkinson’s disease: a perspective of novel clinical subtypes |
title_sort | determinants of quality of life in parkinson’s disease: a perspective of novel clinical subtypes |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8607447/ https://www.ncbi.nlm.nih.gov/pubmed/34716746 http://dx.doi.org/10.1002/acn3.51475 |
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