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Dissecting the Human Response to Staphylococcus aureus Systemic Infections

Staphylococcus aureus is a common human commensal and the leading cause of diverse infections. To identify distinctive parameters associated with infection and colonization, we compared the immune and inflammatory responses of patients with a diagnosis of invasive S. aureus disease to healthy donors...

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Autores principales: Leuzzi, Rosanna, Bodini, Margherita, Thomsen, Isaac P., Soldaini, Elisabetta, Bartolini, Erika, Muzzi, Alessandro, Clemente, Bruna, Galletti, Bruno, Manetti, Andrea Guido Oreste, Giovani, Cinzia, Censini, Stefano, Budroni, Sonia, Spensieri, Fabiana, Borgogni, Erica, Rossi Paccani, Silvia, Margarit, Immaculada, Bagnoli, Fabio, Giudice, Giuseppe Del, Creech, Clarence B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8607524/
https://www.ncbi.nlm.nih.gov/pubmed/34819932
http://dx.doi.org/10.3389/fimmu.2021.749432
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author Leuzzi, Rosanna
Bodini, Margherita
Thomsen, Isaac P.
Soldaini, Elisabetta
Bartolini, Erika
Muzzi, Alessandro
Clemente, Bruna
Galletti, Bruno
Manetti, Andrea Guido Oreste
Giovani, Cinzia
Censini, Stefano
Budroni, Sonia
Spensieri, Fabiana
Borgogni, Erica
Rossi Paccani, Silvia
Margarit, Immaculada
Bagnoli, Fabio
Giudice, Giuseppe Del
Creech, Clarence B.
author_facet Leuzzi, Rosanna
Bodini, Margherita
Thomsen, Isaac P.
Soldaini, Elisabetta
Bartolini, Erika
Muzzi, Alessandro
Clemente, Bruna
Galletti, Bruno
Manetti, Andrea Guido Oreste
Giovani, Cinzia
Censini, Stefano
Budroni, Sonia
Spensieri, Fabiana
Borgogni, Erica
Rossi Paccani, Silvia
Margarit, Immaculada
Bagnoli, Fabio
Giudice, Giuseppe Del
Creech, Clarence B.
author_sort Leuzzi, Rosanna
collection PubMed
description Staphylococcus aureus is a common human commensal and the leading cause of diverse infections. To identify distinctive parameters associated with infection and colonization, we compared the immune and inflammatory responses of patients with a diagnosis of invasive S. aureus disease to healthy donors. We analyzed the inflammatory responses founding a pattern of distinctive cytokines significantly higher in the patients with invasive disease. The measure of antibody levels revealed a wide antibody responsiveness from all subjects to most of the antigens, with significantly higher response for some antigens in the invasive patients compared to control. Moreover, functional antibodies against toxins distinctively associated with the invasive disease. Finally, we examined the genomic variability of isolates, showing no major differences in genetic distribution compared to a panel of representative strains. Overall, our study shows specific signatures of cytokines and functional antibodies in patients with different primary invasive diseases caused by S. aureus. These data provide insight into human responses towards invasive staphylococcal infections and are important for guiding the identification of novel preventive and therapeutic interventions against S. aureus.
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spelling pubmed-86075242021-11-23 Dissecting the Human Response to Staphylococcus aureus Systemic Infections Leuzzi, Rosanna Bodini, Margherita Thomsen, Isaac P. Soldaini, Elisabetta Bartolini, Erika Muzzi, Alessandro Clemente, Bruna Galletti, Bruno Manetti, Andrea Guido Oreste Giovani, Cinzia Censini, Stefano Budroni, Sonia Spensieri, Fabiana Borgogni, Erica Rossi Paccani, Silvia Margarit, Immaculada Bagnoli, Fabio Giudice, Giuseppe Del Creech, Clarence B. Front Immunol Immunology Staphylococcus aureus is a common human commensal and the leading cause of diverse infections. To identify distinctive parameters associated with infection and colonization, we compared the immune and inflammatory responses of patients with a diagnosis of invasive S. aureus disease to healthy donors. We analyzed the inflammatory responses founding a pattern of distinctive cytokines significantly higher in the patients with invasive disease. The measure of antibody levels revealed a wide antibody responsiveness from all subjects to most of the antigens, with significantly higher response for some antigens in the invasive patients compared to control. Moreover, functional antibodies against toxins distinctively associated with the invasive disease. Finally, we examined the genomic variability of isolates, showing no major differences in genetic distribution compared to a panel of representative strains. Overall, our study shows specific signatures of cytokines and functional antibodies in patients with different primary invasive diseases caused by S. aureus. These data provide insight into human responses towards invasive staphylococcal infections and are important for guiding the identification of novel preventive and therapeutic interventions against S. aureus. Frontiers Media S.A. 2021-11-08 /pmc/articles/PMC8607524/ /pubmed/34819932 http://dx.doi.org/10.3389/fimmu.2021.749432 Text en Copyright © 2021 Leuzzi, Bodini, Thomsen, Soldaini, Bartolini, Muzzi, Clemente, Galletti, Manetti, Giovani, Censini, Budroni, Spensieri, Borgogni, Rossi Paccani, Margarit, Bagnoli, Giudice and Creech https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Leuzzi, Rosanna
Bodini, Margherita
Thomsen, Isaac P.
Soldaini, Elisabetta
Bartolini, Erika
Muzzi, Alessandro
Clemente, Bruna
Galletti, Bruno
Manetti, Andrea Guido Oreste
Giovani, Cinzia
Censini, Stefano
Budroni, Sonia
Spensieri, Fabiana
Borgogni, Erica
Rossi Paccani, Silvia
Margarit, Immaculada
Bagnoli, Fabio
Giudice, Giuseppe Del
Creech, Clarence B.
Dissecting the Human Response to Staphylococcus aureus Systemic Infections
title Dissecting the Human Response to Staphylococcus aureus Systemic Infections
title_full Dissecting the Human Response to Staphylococcus aureus Systemic Infections
title_fullStr Dissecting the Human Response to Staphylococcus aureus Systemic Infections
title_full_unstemmed Dissecting the Human Response to Staphylococcus aureus Systemic Infections
title_short Dissecting the Human Response to Staphylococcus aureus Systemic Infections
title_sort dissecting the human response to staphylococcus aureus systemic infections
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8607524/
https://www.ncbi.nlm.nih.gov/pubmed/34819932
http://dx.doi.org/10.3389/fimmu.2021.749432
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