CCR5 antagonist reduces HIV-induced amyloidogenesis, tau pathology, neurodegeneration, and blood-brain barrier alterations in HIV-infected hu-PBL-NSG mice

BACKGROUND: Neurocognitive impairment is present in 50% of HIV-infected individuals and is often associated with Alzheimer’s Disease (AD)-like brain pathologies, including increased amyloid-beta (Aβ) and Tau hyperphosphorylation. Here, we aimed to determine whether HIV-1 infection causes AD-like pat...

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Detalles Bibliográficos
Autores principales: Bhargavan, Biju, Woollard, Shawna M., McMillan, Jo Ellyn, Kanmogne, Georgette D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8607567/
https://www.ncbi.nlm.nih.gov/pubmed/34809709
http://dx.doi.org/10.1186/s13024-021-00500-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8607567/
https://www.ncbi.nlm.nih.gov/pubmed/34809709
http://dx.doi.org/10.1186/s13024-021-00500-0

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