Cargando…
The development of early social cognitive skills in neurogenetic syndromes associated with autism: Cornelia de Lange, fragile X and Rubinstein–Taybi syndromes
BACKGROUND: Cornelia de Lange (CdLS), Fragile X (FXS) and Rubinstein–Taybi syndromes (RTS) evidence unique profiles of autistic characteristics. To delineate these profiles further, the development of early social cognitive abilities in children with CdLS, FXS and RTS was compared to that observed i...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8607585/ https://www.ncbi.nlm.nih.gov/pubmed/34809685 http://dx.doi.org/10.1186/s13023-021-02117-4 |
_version_ | 1784602588806643712 |
---|---|
author | Ellis, Katherine Moss, Jo Stefanidou, Chrysi Oliver, Chris Apperly, Ian |
author_facet | Ellis, Katherine Moss, Jo Stefanidou, Chrysi Oliver, Chris Apperly, Ian |
author_sort | Ellis, Katherine |
collection | PubMed |
description | BACKGROUND: Cornelia de Lange (CdLS), Fragile X (FXS) and Rubinstein–Taybi syndromes (RTS) evidence unique profiles of autistic characteristics. To delineate these profiles further, the development of early social cognitive abilities in children with CdLS, FXS and RTS was compared to that observed in typically developing (TD) and autistic (AUT) children. METHODS: Children with CdLS (N = 22), FXS (N = 19) and RTS (N = 18), completed the Early Social Cognition Scale (ESCogS). Extant data from AUT (N = 19) and TD (N = 86) children were used for comparison. RESULTS: Similar to AUT children, children with CdLS, FXS and RTS showed an overall delay in passing ESCogS tasks. Children with CdLS showed a similar degree of delay to AUT children and greater delay than children with FXS and RTS. The CdLS, FXS and RTS groups did not pass tasks in the same sequence observed in TD and AUT children. Children with CdLS (p = 0.04), FXS (p = 0.02) and RTS (p = 0.04) performed better on tasks requiring understanding simple intentions in others significantly more than tasks requiring joint attention skills. CONCLUSIONS: An underlying mechanism other than general cognitive delay may be disrupting early social cognitive development in children with CdLS, FXS and RTS. Factors that may disrupt early social cognitive development within these syndromes are discussed. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13023-021-02117-4. |
format | Online Article Text |
id | pubmed-8607585 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-86075852021-11-22 The development of early social cognitive skills in neurogenetic syndromes associated with autism: Cornelia de Lange, fragile X and Rubinstein–Taybi syndromes Ellis, Katherine Moss, Jo Stefanidou, Chrysi Oliver, Chris Apperly, Ian Orphanet J Rare Dis Research BACKGROUND: Cornelia de Lange (CdLS), Fragile X (FXS) and Rubinstein–Taybi syndromes (RTS) evidence unique profiles of autistic characteristics. To delineate these profiles further, the development of early social cognitive abilities in children with CdLS, FXS and RTS was compared to that observed in typically developing (TD) and autistic (AUT) children. METHODS: Children with CdLS (N = 22), FXS (N = 19) and RTS (N = 18), completed the Early Social Cognition Scale (ESCogS). Extant data from AUT (N = 19) and TD (N = 86) children were used for comparison. RESULTS: Similar to AUT children, children with CdLS, FXS and RTS showed an overall delay in passing ESCogS tasks. Children with CdLS showed a similar degree of delay to AUT children and greater delay than children with FXS and RTS. The CdLS, FXS and RTS groups did not pass tasks in the same sequence observed in TD and AUT children. Children with CdLS (p = 0.04), FXS (p = 0.02) and RTS (p = 0.04) performed better on tasks requiring understanding simple intentions in others significantly more than tasks requiring joint attention skills. CONCLUSIONS: An underlying mechanism other than general cognitive delay may be disrupting early social cognitive development in children with CdLS, FXS and RTS. Factors that may disrupt early social cognitive development within these syndromes are discussed. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13023-021-02117-4. BioMed Central 2021-11-22 /pmc/articles/PMC8607585/ /pubmed/34809685 http://dx.doi.org/10.1186/s13023-021-02117-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Ellis, Katherine Moss, Jo Stefanidou, Chrysi Oliver, Chris Apperly, Ian The development of early social cognitive skills in neurogenetic syndromes associated with autism: Cornelia de Lange, fragile X and Rubinstein–Taybi syndromes |
title | The development of early social cognitive skills in neurogenetic syndromes associated with autism: Cornelia de Lange, fragile X and Rubinstein–Taybi syndromes |
title_full | The development of early social cognitive skills in neurogenetic syndromes associated with autism: Cornelia de Lange, fragile X and Rubinstein–Taybi syndromes |
title_fullStr | The development of early social cognitive skills in neurogenetic syndromes associated with autism: Cornelia de Lange, fragile X and Rubinstein–Taybi syndromes |
title_full_unstemmed | The development of early social cognitive skills in neurogenetic syndromes associated with autism: Cornelia de Lange, fragile X and Rubinstein–Taybi syndromes |
title_short | The development of early social cognitive skills in neurogenetic syndromes associated with autism: Cornelia de Lange, fragile X and Rubinstein–Taybi syndromes |
title_sort | development of early social cognitive skills in neurogenetic syndromes associated with autism: cornelia de lange, fragile x and rubinstein–taybi syndromes |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8607585/ https://www.ncbi.nlm.nih.gov/pubmed/34809685 http://dx.doi.org/10.1186/s13023-021-02117-4 |
work_keys_str_mv | AT elliskatherine thedevelopmentofearlysocialcognitiveskillsinneurogeneticsyndromesassociatedwithautismcorneliadelangefragilexandrubinsteintaybisyndromes AT mossjo thedevelopmentofearlysocialcognitiveskillsinneurogeneticsyndromesassociatedwithautismcorneliadelangefragilexandrubinsteintaybisyndromes AT stefanidouchrysi thedevelopmentofearlysocialcognitiveskillsinneurogeneticsyndromesassociatedwithautismcorneliadelangefragilexandrubinsteintaybisyndromes AT oliverchris thedevelopmentofearlysocialcognitiveskillsinneurogeneticsyndromesassociatedwithautismcorneliadelangefragilexandrubinsteintaybisyndromes AT apperlyian thedevelopmentofearlysocialcognitiveskillsinneurogeneticsyndromesassociatedwithautismcorneliadelangefragilexandrubinsteintaybisyndromes AT elliskatherine developmentofearlysocialcognitiveskillsinneurogeneticsyndromesassociatedwithautismcorneliadelangefragilexandrubinsteintaybisyndromes AT mossjo developmentofearlysocialcognitiveskillsinneurogeneticsyndromesassociatedwithautismcorneliadelangefragilexandrubinsteintaybisyndromes AT stefanidouchrysi developmentofearlysocialcognitiveskillsinneurogeneticsyndromesassociatedwithautismcorneliadelangefragilexandrubinsteintaybisyndromes AT oliverchris developmentofearlysocialcognitiveskillsinneurogeneticsyndromesassociatedwithautismcorneliadelangefragilexandrubinsteintaybisyndromes AT apperlyian developmentofearlysocialcognitiveskillsinneurogeneticsyndromesassociatedwithautismcorneliadelangefragilexandrubinsteintaybisyndromes |