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The clinical characteristics of patients with pulmonary hypertension combined with obstructive sleep apnoea
OBJECTIVE: Obstructive sleep apnoea (OSA) is one cause of pulmonary hypertension (PH) and can also emerge along with PH. The clinical diagnosis and treatment of OSA in patients with PH are still controversial. The purpose of this clinical observation study was to observe and summarize the incidence...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8607599/ https://www.ncbi.nlm.nih.gov/pubmed/34802431 http://dx.doi.org/10.1186/s12890-021-01755-5 |
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author | Yan, Lu Zhao, Zhihui Zhao, Qing Jin, Qi Zhang, Yi Li, Xin Duan, Anqi Luo, Qin Liu, Zhihong |
author_facet | Yan, Lu Zhao, Zhihui Zhao, Qing Jin, Qi Zhang, Yi Li, Xin Duan, Anqi Luo, Qin Liu, Zhihong |
author_sort | Yan, Lu |
collection | PubMed |
description | OBJECTIVE: Obstructive sleep apnoea (OSA) is one cause of pulmonary hypertension (PH) and can also emerge along with PH. The clinical diagnosis and treatment of OSA in patients with PH are still controversial. The purpose of this clinical observation study was to observe and summarize the incidence and clinical characteristics of OSA in patients with PH and to explore possible predictors of PH combined with OSA. METHODS: Patients with PH diagnosed by right heart catheterization who underwent overnight cardiorespiratory monitoring from December 2018 to December 2020 were enrolled. OSA was defined as an apnoea–hypopnoea index of ≥ 5/h with ≥ 50% of apnoeic events being obstructive. Baseline clinical characteristics and parameters were collected to compare PH patients with and without OSA. Logistic regression analysis was run to determine the risk factors for OSA in PH patients. RESULTS: A total of 35 (25%) of 140 patients had OSA. OSA is relatively frequent in patients with PH, especially in patients with chronic thromboembolic pulmonary hypertension and patients with lung disease– or hypoxia-associated PH. The patients who had OSA were mostly male and had a higher age and a lower daytime arterial oxygen pressure. Logistic regression analysis found that older age, male sex, and lower daytime arterial blood oxygen pressure correlated with OSA in PH patients. CONCLUSION: OSA is common in patients with PH. Lower daytime arterial oxygen pressure is a risk factor for OSA in older male patients with PH. |
format | Online Article Text |
id | pubmed-8607599 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-86075992021-11-22 The clinical characteristics of patients with pulmonary hypertension combined with obstructive sleep apnoea Yan, Lu Zhao, Zhihui Zhao, Qing Jin, Qi Zhang, Yi Li, Xin Duan, Anqi Luo, Qin Liu, Zhihong BMC Pulm Med Research OBJECTIVE: Obstructive sleep apnoea (OSA) is one cause of pulmonary hypertension (PH) and can also emerge along with PH. The clinical diagnosis and treatment of OSA in patients with PH are still controversial. The purpose of this clinical observation study was to observe and summarize the incidence and clinical characteristics of OSA in patients with PH and to explore possible predictors of PH combined with OSA. METHODS: Patients with PH diagnosed by right heart catheterization who underwent overnight cardiorespiratory monitoring from December 2018 to December 2020 were enrolled. OSA was defined as an apnoea–hypopnoea index of ≥ 5/h with ≥ 50% of apnoeic events being obstructive. Baseline clinical characteristics and parameters were collected to compare PH patients with and without OSA. Logistic regression analysis was run to determine the risk factors for OSA in PH patients. RESULTS: A total of 35 (25%) of 140 patients had OSA. OSA is relatively frequent in patients with PH, especially in patients with chronic thromboembolic pulmonary hypertension and patients with lung disease– or hypoxia-associated PH. The patients who had OSA were mostly male and had a higher age and a lower daytime arterial oxygen pressure. Logistic regression analysis found that older age, male sex, and lower daytime arterial blood oxygen pressure correlated with OSA in PH patients. CONCLUSION: OSA is common in patients with PH. Lower daytime arterial oxygen pressure is a risk factor for OSA in older male patients with PH. BioMed Central 2021-11-21 /pmc/articles/PMC8607599/ /pubmed/34802431 http://dx.doi.org/10.1186/s12890-021-01755-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Yan, Lu Zhao, Zhihui Zhao, Qing Jin, Qi Zhang, Yi Li, Xin Duan, Anqi Luo, Qin Liu, Zhihong The clinical characteristics of patients with pulmonary hypertension combined with obstructive sleep apnoea |
title | The clinical characteristics of patients with pulmonary hypertension combined with obstructive sleep apnoea |
title_full | The clinical characteristics of patients with pulmonary hypertension combined with obstructive sleep apnoea |
title_fullStr | The clinical characteristics of patients with pulmonary hypertension combined with obstructive sleep apnoea |
title_full_unstemmed | The clinical characteristics of patients with pulmonary hypertension combined with obstructive sleep apnoea |
title_short | The clinical characteristics of patients with pulmonary hypertension combined with obstructive sleep apnoea |
title_sort | clinical characteristics of patients with pulmonary hypertension combined with obstructive sleep apnoea |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8607599/ https://www.ncbi.nlm.nih.gov/pubmed/34802431 http://dx.doi.org/10.1186/s12890-021-01755-5 |
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