Risk of disease relapse following COVID-19 vaccination in patients with AQP4-IgG-positive NMOSD and MOGAD

Post-vaccination disease relapses have been reported in patients with MOGAD and AQP4-IgG+NMOSD. In this retrospective multicenter Italian study we assessed the frequency of relapses after SARS-CoV-2 vaccination. We included 56 cases: MOGAD, 30; AQP4-IgG+NMOSD, 26. Vaccines received were BNT162b2-Pfi...

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Autores principales: Dinoto, Alessandro, Sechi, Elia, Ferrari, Sergio, Gajofatto, Alberto, Orlandi, Riccardo, Solla, Paolo, Maccabeo, Alessandra, Maniscalco, Giorgia Teresa, Andreone, Vincenzo, Sartori, Arianna, Manganotti, Paolo, Rasia, Sarah, Capra, Ruggero, Mancinelli, Chiara Rosa, Mariotto, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2022
Materias:
Correspondence
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8607690/
https://www.ncbi.nlm.nih.gov/pubmed/35216793
http://dx.doi.org/10.1016/j.msard.2021.103424
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author Dinoto, Alessandro
Sechi, Elia
Ferrari, Sergio
Gajofatto, Alberto
Orlandi, Riccardo
Solla, Paolo
Maccabeo, Alessandra
Maniscalco, Giorgia Teresa
Andreone, Vincenzo
Sartori, Arianna
Manganotti, Paolo
Rasia, Sarah
Capra, Ruggero
Mancinelli, Chiara Rosa
Mariotto, Sara
author_facet Dinoto, Alessandro
Sechi, Elia
Ferrari, Sergio
Gajofatto, Alberto
Orlandi, Riccardo
Solla, Paolo
Maccabeo, Alessandra
Maniscalco, Giorgia Teresa
Andreone, Vincenzo
Sartori, Arianna
Manganotti, Paolo
Rasia, Sarah
Capra, Ruggero
Mancinelli, Chiara Rosa
Mariotto, Sara
author_sort Dinoto, Alessandro
collection PubMed
description Post-vaccination disease relapses have been reported in patients with MOGAD and AQP4-IgG+NMOSD. In this retrospective multicenter Italian study we assessed the frequency of relapses after SARS-CoV-2 vaccination. We included 56 cases: MOGAD, 30; AQP4-IgG+NMOSD, 26. Vaccines received were BNT162b2-Pfizer-BioNTech in 42 patients and mRNA-1273-Moderna in 14 patients. Six patients had a history of SARS-CoV-2 infection; two of them experienced a post-infection disease relapse (MOGAD). The frequency of relapses within one month of SARS-CoV-2 vaccination was 4% (1/26) in the AQP4-IgG+NMOSD group and 0% in the MOGAD group. In these patients the potential benefits of vaccination overcome the risk of relapses.
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spelling pubmed-86076902021-11-22 Risk of disease relapse following COVID-19 vaccination in patients with AQP4-IgG-positive NMOSD and MOGAD Dinoto, Alessandro Sechi, Elia Ferrari, Sergio Gajofatto, Alberto Orlandi, Riccardo Solla, Paolo Maccabeo, Alessandra Maniscalco, Giorgia Teresa Andreone, Vincenzo Sartori, Arianna Manganotti, Paolo Rasia, Sarah Capra, Ruggero Mancinelli, Chiara Rosa Mariotto, Sara Mult Scler Relat Disord Correspondence Post-vaccination disease relapses have been reported in patients with MOGAD and AQP4-IgG+NMOSD. In this retrospective multicenter Italian study we assessed the frequency of relapses after SARS-CoV-2 vaccination. We included 56 cases: MOGAD, 30; AQP4-IgG+NMOSD, 26. Vaccines received were BNT162b2-Pfizer-BioNTech in 42 patients and mRNA-1273-Moderna in 14 patients. Six patients had a history of SARS-CoV-2 infection; two of them experienced a post-infection disease relapse (MOGAD). The frequency of relapses within one month of SARS-CoV-2 vaccination was 4% (1/26) in the AQP4-IgG+NMOSD group and 0% in the MOGAD group. In these patients the potential benefits of vaccination overcome the risk of relapses. Elsevier B.V. 2022-02 2021-11-22 /pmc/articles/PMC8607690/ /pubmed/35216793 http://dx.doi.org/10.1016/j.msard.2021.103424 Text en © 2021 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Correspondence
Dinoto, Alessandro
Sechi, Elia
Ferrari, Sergio
Gajofatto, Alberto
Orlandi, Riccardo
Solla, Paolo
Maccabeo, Alessandra
Maniscalco, Giorgia Teresa
Andreone, Vincenzo
Sartori, Arianna
Manganotti, Paolo
Rasia, Sarah
Capra, Ruggero
Mancinelli, Chiara Rosa
Mariotto, Sara
Risk of disease relapse following COVID-19 vaccination in patients with AQP4-IgG-positive NMOSD and MOGAD
title Risk of disease relapse following COVID-19 vaccination in patients with AQP4-IgG-positive NMOSD and MOGAD
title_full Risk of disease relapse following COVID-19 vaccination in patients with AQP4-IgG-positive NMOSD and MOGAD
title_fullStr Risk of disease relapse following COVID-19 vaccination in patients with AQP4-IgG-positive NMOSD and MOGAD
title_full_unstemmed Risk of disease relapse following COVID-19 vaccination in patients with AQP4-IgG-positive NMOSD and MOGAD
title_short Risk of disease relapse following COVID-19 vaccination in patients with AQP4-IgG-positive NMOSD and MOGAD
title_sort risk of disease relapse following covid-19 vaccination in patients with aqp4-igg-positive nmosd and mogad
topic Correspondence
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8607690/
https://www.ncbi.nlm.nih.gov/pubmed/35216793
http://dx.doi.org/10.1016/j.msard.2021.103424
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