Targeted integration of EpCAM-specific CAR in human induced pluripotent stem cells and their differentiation into NK cells

BACKGROUND: Redirection of natural killer (NK) cells with chimeric antigen receptors (CAR) is attractive in developing off-the-shelf CAR therapeutics for cancer treatment. However, the site-specific integration of a CAR gene into NK cells remains challenging. METHODS: In the present study, we geneti...

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Detalles Bibliográficos
Autores principales: Tang, Shin Yi, Zha, Shijun, Du, Zhicheng, Zeng, Jieming, Zhu, Detu, Luo, Yumei, Wang, Shu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8607711/
https://www.ncbi.nlm.nih.gov/pubmed/34802459
http://dx.doi.org/10.1186/s13287-021-02648-4

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