Lamotrigine‐induced neutropenia after high‐dose concomitant initiation with phenytoin

Lamotrigine has been repeatedly reported to cause hematologic toxicities, which may be associated with high initial doses or excessive escalation. A 29‐year‐old lady experienced profound neutropenia after two weeks of lamotrigine high initial dose, started within two days of phenytoin. The too‐early...

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Detalles Bibliográficos
Autores principales: Salem, Muhammad, El‐Bardissy, Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8607801/
https://www.ncbi.nlm.nih.gov/pubmed/34849233
http://dx.doi.org/10.1002/ccr3.5136
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author Salem, Muhammad
El‐Bardissy, Ahmed
author_facet Salem, Muhammad
El‐Bardissy, Ahmed
author_sort Salem, Muhammad
collection PubMed
description Lamotrigine has been repeatedly reported to cause hematologic toxicities, which may be associated with high initial doses or excessive escalation. A 29‐year‐old lady experienced profound neutropenia after two weeks of lamotrigine high initial dose, started within two days of phenytoin. The too‐early dose intensification may have produced lamotrigine‐induced blood dyscrasia.
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spelling pubmed-86078012021-11-29 Lamotrigine‐induced neutropenia after high‐dose concomitant initiation with phenytoin Salem, Muhammad El‐Bardissy, Ahmed Clin Case Rep Case Report Lamotrigine has been repeatedly reported to cause hematologic toxicities, which may be associated with high initial doses or excessive escalation. A 29‐year‐old lady experienced profound neutropenia after two weeks of lamotrigine high initial dose, started within two days of phenytoin. The too‐early dose intensification may have produced lamotrigine‐induced blood dyscrasia. John Wiley and Sons Inc. 2021-11-22 /pmc/articles/PMC8607801/ /pubmed/34849233 http://dx.doi.org/10.1002/ccr3.5136 Text en © 2021 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Salem, Muhammad
El‐Bardissy, Ahmed
Lamotrigine‐induced neutropenia after high‐dose concomitant initiation with phenytoin
title Lamotrigine‐induced neutropenia after high‐dose concomitant initiation with phenytoin
title_full Lamotrigine‐induced neutropenia after high‐dose concomitant initiation with phenytoin
title_fullStr Lamotrigine‐induced neutropenia after high‐dose concomitant initiation with phenytoin
title_full_unstemmed Lamotrigine‐induced neutropenia after high‐dose concomitant initiation with phenytoin
title_short Lamotrigine‐induced neutropenia after high‐dose concomitant initiation with phenytoin
title_sort lamotrigine‐induced neutropenia after high‐dose concomitant initiation with phenytoin
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8607801/
https://www.ncbi.nlm.nih.gov/pubmed/34849233
http://dx.doi.org/10.1002/ccr3.5136
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