Senolytics reduce coronavirus-related mortality in old mice

The COVID-19 pandemic has revealed the pronounced vulnerability of the elderly and chronically ill to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–induced morbidity and mortality. Cellular senescence contributes to inflammation, multiple chronic diseases, and age-related dysfunction,...

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Detalles Bibliográficos
Autores principales: Camell, Christina D., Yousefzadeh, Matthew J., Zhu, Yi, Prata, Larissa G. P. Langhi, Huggins, Matthew A., Pierson, Mark, Zhang, Lei, O’Kelly, Ryan D., Pirtskhalava, Tamar, Xun, Pengcheng, Ejima, Keisuke, Xue, Ailing, Tripathi, Utkarsh, Espindola-Netto, Jair Machado, Giorgadze, Nino, Atkinson, Elizabeth J., Inman, Christina L., Johnson, Kurt O., Cholensky, Stephanie H., Carlson, Timothy W., LeBrasseur, Nathan K., Khosla, Sundeep, O’Sullivan, M. Gerard, Allison, David B., Jameson, Stephen C., Meves, Alexander, Li, Ming, Prakash, Y. S., Chiarella, Sergio E., Hamilton, Sara E., Tchkonia, Tamara, Niedernhofer, Laura J., Kirkland, James L., Robbins, Paul D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8607935/
https://www.ncbi.nlm.nih.gov/pubmed/34103349
http://dx.doi.org/10.1126/science.abe4832

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