Cargando…
Cancer metabolism and intervention therapy
Metabolic reprogramming with heterogeneity is a hallmark of cancer and is at the basis of malignant behaviors. It supports the proliferation and metastasis of tumor cells according to the low nutrition and hypoxic microenvironment. Tumor cells frantically grab energy sources (such as glucose, fatty...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Singapore
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8607959/ https://www.ncbi.nlm.nih.gov/pubmed/35006438 http://dx.doi.org/10.1186/s43556-020-00012-1 |
_version_ | 1784602664759197696 |
---|---|
author | Zhao, Huakan Li, Yongsheng |
author_facet | Zhao, Huakan Li, Yongsheng |
author_sort | Zhao, Huakan |
collection | PubMed |
description | Metabolic reprogramming with heterogeneity is a hallmark of cancer and is at the basis of malignant behaviors. It supports the proliferation and metastasis of tumor cells according to the low nutrition and hypoxic microenvironment. Tumor cells frantically grab energy sources (such as glucose, fatty acids, and glutamine) from different pathways to produce a variety of biomass to meet their material needs via enhanced synthetic pathways, including aerobic glycolysis, glutaminolysis, fatty acid synthesis (FAS), and pentose phosphate pathway (PPP). To survive from stress conditions (e.g., metastasis, irradiation, or chemotherapy), tumor cells have to reprogram their metabolism from biomass production towards the generation of abundant adenosine triphosphate (ATP) and antioxidants. In addition, cancer cells remodel the microenvironment through metabolites, promoting an immunosuppressive microenvironment. Herein, we discuss how the metabolism is reprogrammed in cancer cells and how the tumor microenvironment is educated via the metabolic products. We also highlight potential metabolic targets for cancer therapies. |
format | Online Article Text |
id | pubmed-8607959 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Singapore |
record_format | MEDLINE/PubMed |
spelling | pubmed-86079592021-12-01 Cancer metabolism and intervention therapy Zhao, Huakan Li, Yongsheng Mol Biomed Review Metabolic reprogramming with heterogeneity is a hallmark of cancer and is at the basis of malignant behaviors. It supports the proliferation and metastasis of tumor cells according to the low nutrition and hypoxic microenvironment. Tumor cells frantically grab energy sources (such as glucose, fatty acids, and glutamine) from different pathways to produce a variety of biomass to meet their material needs via enhanced synthetic pathways, including aerobic glycolysis, glutaminolysis, fatty acid synthesis (FAS), and pentose phosphate pathway (PPP). To survive from stress conditions (e.g., metastasis, irradiation, or chemotherapy), tumor cells have to reprogram their metabolism from biomass production towards the generation of abundant adenosine triphosphate (ATP) and antioxidants. In addition, cancer cells remodel the microenvironment through metabolites, promoting an immunosuppressive microenvironment. Herein, we discuss how the metabolism is reprogrammed in cancer cells and how the tumor microenvironment is educated via the metabolic products. We also highlight potential metabolic targets for cancer therapies. Springer Singapore 2021-02-20 /pmc/articles/PMC8607959/ /pubmed/35006438 http://dx.doi.org/10.1186/s43556-020-00012-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Zhao, Huakan Li, Yongsheng Cancer metabolism and intervention therapy |
title | Cancer metabolism and intervention therapy |
title_full | Cancer metabolism and intervention therapy |
title_fullStr | Cancer metabolism and intervention therapy |
title_full_unstemmed | Cancer metabolism and intervention therapy |
title_short | Cancer metabolism and intervention therapy |
title_sort | cancer metabolism and intervention therapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8607959/ https://www.ncbi.nlm.nih.gov/pubmed/35006438 http://dx.doi.org/10.1186/s43556-020-00012-1 |
work_keys_str_mv | AT zhaohuakan cancermetabolismandinterventiontherapy AT liyongsheng cancermetabolismandinterventiontherapy |