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Respiratory symptoms and respiratory deaths: A multi-cohort study with 45 years observation time
This study determined the association between respiratory symptoms and death from respiratory causes over a period of 45 years. In four cohorts of random samples of Norwegian populations with 103,881 participants, 43,731 persons had died per 31 December 2016. In total, 5,949 (14%) had died from resp...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Public Library of Science
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8608323/ https://www.ncbi.nlm.nih.gov/pubmed/34807953 http://dx.doi.org/10.1371/journal.pone.0260416 |
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author | Stavem, Knut Johannessen, Ane Nielsen, Rune Gulsvik, Amund |
author_facet | Stavem, Knut Johannessen, Ane Nielsen, Rune Gulsvik, Amund |
author_sort | Stavem, Knut |
collection | PubMed |
description | This study determined the association between respiratory symptoms and death from respiratory causes over a period of 45 years. In four cohorts of random samples of Norwegian populations with 103,881 participants, 43,731 persons had died per 31 December 2016. In total, 5,949 (14%) had died from respiratory diseases; 2,442 (41%) from lung cancer, 1,717 (29%) chronic obstructive pulmonary disease (COPD), 1,348 (23%) pneumonia, 119 (2%) asthma, 147 (2%) interstitial lung disease and 176 (3%) other pulmonary diseases. Compared with persons without respiratory symptoms the multivariable adjusted hazard ratio (HR) for lung cancer deaths increased with score of breathlessness on effort and cough and phlegm, being 2.6 (95% CI 2.1–3.2) for breathlessness score 3 and 2.1 (95% CI 1.7–2.5) for cough and phlegm score 5. The HR of COPD death was 6.4 (95% CI 5.4–7.7) for breathlessness score 3 and 3.0 (2.4–3.6) for cough and phlegm score 5. Attacks of breathlessness and wheeze score 2 had a HR of 1.6 (1.4–1.9) for COPD death. The risk of pneumonia deaths increased also with higher breathlessness on effort score, but not with higher cough and phlegm score, except for score 2 with HR 1.5 (1.2–1.8). In this study with >2.4 million person-years at risk, a positive association was observed between scores of respiratory symptoms and deaths due to COPD and lung cancer. Respiratory symptoms are thus important risk factors, which should be followed thoroughly by health care practitioners for the benefit of public health. |
format | Online Article Text |
id | pubmed-8608323 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-86083232021-11-23 Respiratory symptoms and respiratory deaths: A multi-cohort study with 45 years observation time Stavem, Knut Johannessen, Ane Nielsen, Rune Gulsvik, Amund PLoS One Research Article This study determined the association between respiratory symptoms and death from respiratory causes over a period of 45 years. In four cohorts of random samples of Norwegian populations with 103,881 participants, 43,731 persons had died per 31 December 2016. In total, 5,949 (14%) had died from respiratory diseases; 2,442 (41%) from lung cancer, 1,717 (29%) chronic obstructive pulmonary disease (COPD), 1,348 (23%) pneumonia, 119 (2%) asthma, 147 (2%) interstitial lung disease and 176 (3%) other pulmonary diseases. Compared with persons without respiratory symptoms the multivariable adjusted hazard ratio (HR) for lung cancer deaths increased with score of breathlessness on effort and cough and phlegm, being 2.6 (95% CI 2.1–3.2) for breathlessness score 3 and 2.1 (95% CI 1.7–2.5) for cough and phlegm score 5. The HR of COPD death was 6.4 (95% CI 5.4–7.7) for breathlessness score 3 and 3.0 (2.4–3.6) for cough and phlegm score 5. Attacks of breathlessness and wheeze score 2 had a HR of 1.6 (1.4–1.9) for COPD death. The risk of pneumonia deaths increased also with higher breathlessness on effort score, but not with higher cough and phlegm score, except for score 2 with HR 1.5 (1.2–1.8). In this study with >2.4 million person-years at risk, a positive association was observed between scores of respiratory symptoms and deaths due to COPD and lung cancer. Respiratory symptoms are thus important risk factors, which should be followed thoroughly by health care practitioners for the benefit of public health. Public Library of Science 2021-11-22 /pmc/articles/PMC8608323/ /pubmed/34807953 http://dx.doi.org/10.1371/journal.pone.0260416 Text en © 2021 Stavem et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Stavem, Knut Johannessen, Ane Nielsen, Rune Gulsvik, Amund Respiratory symptoms and respiratory deaths: A multi-cohort study with 45 years observation time |
title | Respiratory symptoms and respiratory deaths: A multi-cohort study with 45 years observation time |
title_full | Respiratory symptoms and respiratory deaths: A multi-cohort study with 45 years observation time |
title_fullStr | Respiratory symptoms and respiratory deaths: A multi-cohort study with 45 years observation time |
title_full_unstemmed | Respiratory symptoms and respiratory deaths: A multi-cohort study with 45 years observation time |
title_short | Respiratory symptoms and respiratory deaths: A multi-cohort study with 45 years observation time |
title_sort | respiratory symptoms and respiratory deaths: a multi-cohort study with 45 years observation time |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8608323/ https://www.ncbi.nlm.nih.gov/pubmed/34807953 http://dx.doi.org/10.1371/journal.pone.0260416 |
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