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Respiratory symptoms and respiratory deaths: A multi-cohort study with 45 years observation time

This study determined the association between respiratory symptoms and death from respiratory causes over a period of 45 years. In four cohorts of random samples of Norwegian populations with 103,881 participants, 43,731 persons had died per 31 December 2016. In total, 5,949 (14%) had died from resp...

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Detalles Bibliográficos
Autores principales: Stavem, Knut, Johannessen, Ane, Nielsen, Rune, Gulsvik, Amund
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8608323/
https://www.ncbi.nlm.nih.gov/pubmed/34807953
http://dx.doi.org/10.1371/journal.pone.0260416
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author Stavem, Knut
Johannessen, Ane
Nielsen, Rune
Gulsvik, Amund
author_facet Stavem, Knut
Johannessen, Ane
Nielsen, Rune
Gulsvik, Amund
author_sort Stavem, Knut
collection PubMed
description This study determined the association between respiratory symptoms and death from respiratory causes over a period of 45 years. In four cohorts of random samples of Norwegian populations with 103,881 participants, 43,731 persons had died per 31 December 2016. In total, 5,949 (14%) had died from respiratory diseases; 2,442 (41%) from lung cancer, 1,717 (29%) chronic obstructive pulmonary disease (COPD), 1,348 (23%) pneumonia, 119 (2%) asthma, 147 (2%) interstitial lung disease and 176 (3%) other pulmonary diseases. Compared with persons without respiratory symptoms the multivariable adjusted hazard ratio (HR) for lung cancer deaths increased with score of breathlessness on effort and cough and phlegm, being 2.6 (95% CI 2.1–3.2) for breathlessness score 3 and 2.1 (95% CI 1.7–2.5) for cough and phlegm score 5. The HR of COPD death was 6.4 (95% CI 5.4–7.7) for breathlessness score 3 and 3.0 (2.4–3.6) for cough and phlegm score 5. Attacks of breathlessness and wheeze score 2 had a HR of 1.6 (1.4–1.9) for COPD death. The risk of pneumonia deaths increased also with higher breathlessness on effort score, but not with higher cough and phlegm score, except for score 2 with HR 1.5 (1.2–1.8). In this study with >2.4 million person-years at risk, a positive association was observed between scores of respiratory symptoms and deaths due to COPD and lung cancer. Respiratory symptoms are thus important risk factors, which should be followed thoroughly by health care practitioners for the benefit of public health.
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spelling pubmed-86083232021-11-23 Respiratory symptoms and respiratory deaths: A multi-cohort study with 45 years observation time Stavem, Knut Johannessen, Ane Nielsen, Rune Gulsvik, Amund PLoS One Research Article This study determined the association between respiratory symptoms and death from respiratory causes over a period of 45 years. In four cohorts of random samples of Norwegian populations with 103,881 participants, 43,731 persons had died per 31 December 2016. In total, 5,949 (14%) had died from respiratory diseases; 2,442 (41%) from lung cancer, 1,717 (29%) chronic obstructive pulmonary disease (COPD), 1,348 (23%) pneumonia, 119 (2%) asthma, 147 (2%) interstitial lung disease and 176 (3%) other pulmonary diseases. Compared with persons without respiratory symptoms the multivariable adjusted hazard ratio (HR) for lung cancer deaths increased with score of breathlessness on effort and cough and phlegm, being 2.6 (95% CI 2.1–3.2) for breathlessness score 3 and 2.1 (95% CI 1.7–2.5) for cough and phlegm score 5. The HR of COPD death was 6.4 (95% CI 5.4–7.7) for breathlessness score 3 and 3.0 (2.4–3.6) for cough and phlegm score 5. Attacks of breathlessness and wheeze score 2 had a HR of 1.6 (1.4–1.9) for COPD death. The risk of pneumonia deaths increased also with higher breathlessness on effort score, but not with higher cough and phlegm score, except for score 2 with HR 1.5 (1.2–1.8). In this study with >2.4 million person-years at risk, a positive association was observed between scores of respiratory symptoms and deaths due to COPD and lung cancer. Respiratory symptoms are thus important risk factors, which should be followed thoroughly by health care practitioners for the benefit of public health. Public Library of Science 2021-11-22 /pmc/articles/PMC8608323/ /pubmed/34807953 http://dx.doi.org/10.1371/journal.pone.0260416 Text en © 2021 Stavem et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Stavem, Knut
Johannessen, Ane
Nielsen, Rune
Gulsvik, Amund
Respiratory symptoms and respiratory deaths: A multi-cohort study with 45 years observation time
title Respiratory symptoms and respiratory deaths: A multi-cohort study with 45 years observation time
title_full Respiratory symptoms and respiratory deaths: A multi-cohort study with 45 years observation time
title_fullStr Respiratory symptoms and respiratory deaths: A multi-cohort study with 45 years observation time
title_full_unstemmed Respiratory symptoms and respiratory deaths: A multi-cohort study with 45 years observation time
title_short Respiratory symptoms and respiratory deaths: A multi-cohort study with 45 years observation time
title_sort respiratory symptoms and respiratory deaths: a multi-cohort study with 45 years observation time
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8608323/
https://www.ncbi.nlm.nih.gov/pubmed/34807953
http://dx.doi.org/10.1371/journal.pone.0260416
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