Primary urethral melanoma treated sucessfully with wide excision and combination immunotherapy: Case report and review of literature

We report the rare case of a primary malignant melanoma of the urethra. An 89-year-old African American woman who was referred to our urology clinic for intermittent gross hematuria and a palpable vaginal mass of two months duration. Cystoscopy revealed a 3 cm mass in the distal urethra and urethral...

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Autores principales: Martinez, Mariela, Kotamarti, Srinath, Schulman, Ariel, Mooppan, Unni, Wang, Jen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8608589/
https://www.ncbi.nlm.nih.gov/pubmed/34849344
http://dx.doi.org/10.1016/j.eucr.2021.101835
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author Martinez, Mariela
Kotamarti, Srinath
Schulman, Ariel
Mooppan, Unni
Wang, Jen
author_facet Martinez, Mariela
Kotamarti, Srinath
Schulman, Ariel
Mooppan, Unni
Wang, Jen
author_sort Martinez, Mariela
collection PubMed
description We report the rare case of a primary malignant melanoma of the urethra. An 89-year-old African American woman who was referred to our urology clinic for intermittent gross hematuria and a palpable vaginal mass of two months duration. Cystoscopy revealed a 3 cm mass in the distal urethra and urethral meatus that was surgically resected by wide local excision. The histopathologic diagnosis was primary malignant melanoma of the urethra. The patient was subsequently treated with adjuvant EBRT and immunotherapy with nivolumab and ipilimumab. Post-treatment PET-CT showed good response to treatment and patient remained in remission at eight month follow up.
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spelling pubmed-86085892021-11-29 Primary urethral melanoma treated sucessfully with wide excision and combination immunotherapy: Case report and review of literature Martinez, Mariela Kotamarti, Srinath Schulman, Ariel Mooppan, Unni Wang, Jen Urol Case Rep Oncology We report the rare case of a primary malignant melanoma of the urethra. An 89-year-old African American woman who was referred to our urology clinic for intermittent gross hematuria and a palpable vaginal mass of two months duration. Cystoscopy revealed a 3 cm mass in the distal urethra and urethral meatus that was surgically resected by wide local excision. The histopathologic diagnosis was primary malignant melanoma of the urethra. The patient was subsequently treated with adjuvant EBRT and immunotherapy with nivolumab and ipilimumab. Post-treatment PET-CT showed good response to treatment and patient remained in remission at eight month follow up. Elsevier 2021-09-20 /pmc/articles/PMC8608589/ /pubmed/34849344 http://dx.doi.org/10.1016/j.eucr.2021.101835 Text en © 2021 Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Oncology
Martinez, Mariela
Kotamarti, Srinath
Schulman, Ariel
Mooppan, Unni
Wang, Jen
Primary urethral melanoma treated sucessfully with wide excision and combination immunotherapy: Case report and review of literature
title Primary urethral melanoma treated sucessfully with wide excision and combination immunotherapy: Case report and review of literature
title_full Primary urethral melanoma treated sucessfully with wide excision and combination immunotherapy: Case report and review of literature
title_fullStr Primary urethral melanoma treated sucessfully with wide excision and combination immunotherapy: Case report and review of literature
title_full_unstemmed Primary urethral melanoma treated sucessfully with wide excision and combination immunotherapy: Case report and review of literature
title_short Primary urethral melanoma treated sucessfully with wide excision and combination immunotherapy: Case report and review of literature
title_sort primary urethral melanoma treated sucessfully with wide excision and combination immunotherapy: case report and review of literature
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8608589/
https://www.ncbi.nlm.nih.gov/pubmed/34849344
http://dx.doi.org/10.1016/j.eucr.2021.101835
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