FLT3-ITD transduces autonomous growth signals during its biosynthetic trafficking in acute myelogenous leukemia cells

FMS-like tyrosine kinase 3 (FLT3) in hematopoietic cells binds to its ligand at the plasma membrane (PM), then transduces growth signals. FLT3 gene alterations that lead the kinase to assume its permanently active form, such as internal tandem duplication (ITD) and D835Y substitution, are found in 3...

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Detalles Bibliográficos
Autores principales: Yamawaki, Kouhei, Shiina, Isamu, Murata, Takatsugu, Tateyama, Satoru, Maekawa, Yutarou, Niwa, Mariko, Shimonaka, Motoyuki, Okamoto, Koji, Suzuki, Toshihiro, Nishida, Toshirou, Abe, Ryo, Obata, Yuuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8608843/
https://www.ncbi.nlm.nih.gov/pubmed/34811450
http://dx.doi.org/10.1038/s41598-021-02221-2

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