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Multimodal characterization of Yucatan minipig behavior and physiology through maturation

Brain injuries induced by external forces are particularly challenging to model experimentally. In recent decades, the domestic pig has been gaining popularity as a highly relevant animal model to address the pathophysiological mechanisms and the biomechanics associated with head injuries. Understan...

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Autores principales: Netzley, Alesa H., Hunt, Ryan D., Franco-Arellano, Josue, Arnold, Nicole, Vazquez, Ana I., Munoz, Kirk A., Colbath, Aimee C., Bush, Tamara Reid, Pelled, Galit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8608884/
https://www.ncbi.nlm.nih.gov/pubmed/34811385
http://dx.doi.org/10.1038/s41598-021-00782-w
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author Netzley, Alesa H.
Hunt, Ryan D.
Franco-Arellano, Josue
Arnold, Nicole
Vazquez, Ana I.
Munoz, Kirk A.
Colbath, Aimee C.
Bush, Tamara Reid
Pelled, Galit
author_facet Netzley, Alesa H.
Hunt, Ryan D.
Franco-Arellano, Josue
Arnold, Nicole
Vazquez, Ana I.
Munoz, Kirk A.
Colbath, Aimee C.
Bush, Tamara Reid
Pelled, Galit
author_sort Netzley, Alesa H.
collection PubMed
description Brain injuries induced by external forces are particularly challenging to model experimentally. In recent decades, the domestic pig has been gaining popularity as a highly relevant animal model to address the pathophysiological mechanisms and the biomechanics associated with head injuries. Understanding cognitive, motor, and sensory aspects of pig behavior throughout development is crucial for evaluating cognitive and motor deficits after injury. We have developed a comprehensive battery of tests to characterize the behavior and physiological function of the Yucatan minipig throughout maturation. Behavioral testing included assessments of learning and memory, executive functions, circadian rhythms, gait analysis, and level of motor activity. We applied traditional behavioral apparatus and analysis methods, as well as state-of-the-art sensor technologies to report on motion and activity, and artificial intelligent approaches to analyze behavior. We studied pigs from 16 weeks old through sexual maturity at 35 weeks old. The results show multidimensional characterization of minipig behavior, and how it develops and changes with age. This animal model may capitulate the biomechanical consideration and phenotype of head injuries in the developing brain and can drive forward the field of understanding pathophysiological mechanisms and developing new therapies to accelerate recovery in children who have suffered head trauma.
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spelling pubmed-86088842021-11-24 Multimodal characterization of Yucatan minipig behavior and physiology through maturation Netzley, Alesa H. Hunt, Ryan D. Franco-Arellano, Josue Arnold, Nicole Vazquez, Ana I. Munoz, Kirk A. Colbath, Aimee C. Bush, Tamara Reid Pelled, Galit Sci Rep Article Brain injuries induced by external forces are particularly challenging to model experimentally. In recent decades, the domestic pig has been gaining popularity as a highly relevant animal model to address the pathophysiological mechanisms and the biomechanics associated with head injuries. Understanding cognitive, motor, and sensory aspects of pig behavior throughout development is crucial for evaluating cognitive and motor deficits after injury. We have developed a comprehensive battery of tests to characterize the behavior and physiological function of the Yucatan minipig throughout maturation. Behavioral testing included assessments of learning and memory, executive functions, circadian rhythms, gait analysis, and level of motor activity. We applied traditional behavioral apparatus and analysis methods, as well as state-of-the-art sensor technologies to report on motion and activity, and artificial intelligent approaches to analyze behavior. We studied pigs from 16 weeks old through sexual maturity at 35 weeks old. The results show multidimensional characterization of minipig behavior, and how it develops and changes with age. This animal model may capitulate the biomechanical consideration and phenotype of head injuries in the developing brain and can drive forward the field of understanding pathophysiological mechanisms and developing new therapies to accelerate recovery in children who have suffered head trauma. Nature Publishing Group UK 2021-11-22 /pmc/articles/PMC8608884/ /pubmed/34811385 http://dx.doi.org/10.1038/s41598-021-00782-w Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Netzley, Alesa H.
Hunt, Ryan D.
Franco-Arellano, Josue
Arnold, Nicole
Vazquez, Ana I.
Munoz, Kirk A.
Colbath, Aimee C.
Bush, Tamara Reid
Pelled, Galit
Multimodal characterization of Yucatan minipig behavior and physiology through maturation
title Multimodal characterization of Yucatan minipig behavior and physiology through maturation
title_full Multimodal characterization of Yucatan minipig behavior and physiology through maturation
title_fullStr Multimodal characterization of Yucatan minipig behavior and physiology through maturation
title_full_unstemmed Multimodal characterization of Yucatan minipig behavior and physiology through maturation
title_short Multimodal characterization of Yucatan minipig behavior and physiology through maturation
title_sort multimodal characterization of yucatan minipig behavior and physiology through maturation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8608884/
https://www.ncbi.nlm.nih.gov/pubmed/34811385
http://dx.doi.org/10.1038/s41598-021-00782-w
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