Exploiting lipotoxicity for the treatment of liver cancer

Metabolic alterations occur frequently in solid tumours, but metabolic cancer therapies are limited by the complexity and plasticity of metabolic networks. We could recently show that activation of the liver X receptor alpha (LXRα) and inhibition of a Raf-1-SCD1 protein complex induces an intracellu...

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Autores principales: Rudalska, Ramona, Zender, Lars, Dauch, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8608911/
https://www.ncbi.nlm.nih.gov/pubmed/34302061
http://dx.doi.org/10.1038/s41416-021-01479-7
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author Rudalska, Ramona
Zender, Lars
Dauch, Daniel
author_facet Rudalska, Ramona
Zender, Lars
Dauch, Daniel
author_sort Rudalska, Ramona
collection PubMed
description Metabolic alterations occur frequently in solid tumours, but metabolic cancer therapies are limited by the complexity and plasticity of metabolic networks. We could recently show that activation of the liver X receptor alpha (LXRα) and inhibition of a Raf-1-SCD1 protein complex induces an intracellular accumulation of saturated free fatty acids leading to lethal lipotoxicity in tumour cells and allows for an efficient treatment of liver carcinomas.
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spelling pubmed-86089112021-12-01 Exploiting lipotoxicity for the treatment of liver cancer Rudalska, Ramona Zender, Lars Dauch, Daniel Br J Cancer Comment Metabolic alterations occur frequently in solid tumours, but metabolic cancer therapies are limited by the complexity and plasticity of metabolic networks. We could recently show that activation of the liver X receptor alpha (LXRα) and inhibition of a Raf-1-SCD1 protein complex induces an intracellular accumulation of saturated free fatty acids leading to lethal lipotoxicity in tumour cells and allows for an efficient treatment of liver carcinomas. Nature Publishing Group UK 2021-07-23 2021-11-23 /pmc/articles/PMC8608911/ /pubmed/34302061 http://dx.doi.org/10.1038/s41416-021-01479-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Comment
Rudalska, Ramona
Zender, Lars
Dauch, Daniel
Exploiting lipotoxicity for the treatment of liver cancer
title Exploiting lipotoxicity for the treatment of liver cancer
title_full Exploiting lipotoxicity for the treatment of liver cancer
title_fullStr Exploiting lipotoxicity for the treatment of liver cancer
title_full_unstemmed Exploiting lipotoxicity for the treatment of liver cancer
title_short Exploiting lipotoxicity for the treatment of liver cancer
title_sort exploiting lipotoxicity for the treatment of liver cancer
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8608911/
https://www.ncbi.nlm.nih.gov/pubmed/34302061
http://dx.doi.org/10.1038/s41416-021-01479-7
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