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FSH levels and testicular volumes are associated with the severity of testicular histopathology in men with non-obstructive azoospermia

PURPOSE: The purpose of this study is to assess a potential association between FSH levels and testicular volumes with the severity of testicular histopathology on testicular biopsy in men with non-obstructive azoospermia (NOA) undergoing microdissection testicular sperm extraction (microTESE). METH...

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Autores principales: Kavoussi, Parviz K., Hudson, Kayla, Machen, G. Luke, Barsky, Maya, Lebovic, Dan I., Kavoussi, Shahryar K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8608933/
https://www.ncbi.nlm.nih.gov/pubmed/34532836
http://dx.doi.org/10.1007/s10815-021-02313-y
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author Kavoussi, Parviz K.
Hudson, Kayla
Machen, G. Luke
Barsky, Maya
Lebovic, Dan I.
Kavoussi, Shahryar K.
author_facet Kavoussi, Parviz K.
Hudson, Kayla
Machen, G. Luke
Barsky, Maya
Lebovic, Dan I.
Kavoussi, Shahryar K.
author_sort Kavoussi, Parviz K.
collection PubMed
description PURPOSE: The purpose of this study is to assess a potential association between FSH levels and testicular volumes with the severity of testicular histopathology on testicular biopsy in men with non-obstructive azoospermia (NOA) undergoing microdissection testicular sperm extraction (microTESE). METHODS: A retrospective chart review was performed from the electronic health records of men who underwent microTESE with NOA. RESULTS: Eighty-six men with NOA underwent microTESE with concomitant testicular biopsy for permanent section to assess the testicular cellular architecture. The histopathological patterns were categorized by severity indicating the odds of sperm retrieval into 2 categories. The unfavorable category included Sertoli cell only pattern and early maturation arrest (n = 50) and the favorable category included late maturation arrest and hypospermatogenesis patterns (n = 36). In the men with unfavorable histopathologic patterns, the mean FSH level was 22.9 ± 16.6 IU/L, and the mean testicular volume was 10.4 ± 6.0 cc. This was in comparison to men with favorable histopathologic patterns revealing a mean FSH level of FSH 13.3 ± 12.0 with a mean testicular volume of 13.3 ± 5.9 cc. There was a statistically significant higher FSH level in men with unfavorable histopathology than favorable (p = 0.004) as well as a significant smaller mean testicular volume in men with unfavorable histopathology (p = 0.029). CONCLUSIONS: Higher serum FSH levels and smaller testicular volumes are associated with more severe testicular histopathological patterns in men with NOA.
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spelling pubmed-86089332021-12-03 FSH levels and testicular volumes are associated with the severity of testicular histopathology in men with non-obstructive azoospermia Kavoussi, Parviz K. Hudson, Kayla Machen, G. Luke Barsky, Maya Lebovic, Dan I. Kavoussi, Shahryar K. J Assist Reprod Genet Reproductive Physiology and Disease PURPOSE: The purpose of this study is to assess a potential association between FSH levels and testicular volumes with the severity of testicular histopathology on testicular biopsy in men with non-obstructive azoospermia (NOA) undergoing microdissection testicular sperm extraction (microTESE). METHODS: A retrospective chart review was performed from the electronic health records of men who underwent microTESE with NOA. RESULTS: Eighty-six men with NOA underwent microTESE with concomitant testicular biopsy for permanent section to assess the testicular cellular architecture. The histopathological patterns were categorized by severity indicating the odds of sperm retrieval into 2 categories. The unfavorable category included Sertoli cell only pattern and early maturation arrest (n = 50) and the favorable category included late maturation arrest and hypospermatogenesis patterns (n = 36). In the men with unfavorable histopathologic patterns, the mean FSH level was 22.9 ± 16.6 IU/L, and the mean testicular volume was 10.4 ± 6.0 cc. This was in comparison to men with favorable histopathologic patterns revealing a mean FSH level of FSH 13.3 ± 12.0 with a mean testicular volume of 13.3 ± 5.9 cc. There was a statistically significant higher FSH level in men with unfavorable histopathology than favorable (p = 0.004) as well as a significant smaller mean testicular volume in men with unfavorable histopathology (p = 0.029). CONCLUSIONS: Higher serum FSH levels and smaller testicular volumes are associated with more severe testicular histopathological patterns in men with NOA. Springer US 2021-09-17 2021-11 /pmc/articles/PMC8608933/ /pubmed/34532836 http://dx.doi.org/10.1007/s10815-021-02313-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Reproductive Physiology and Disease
Kavoussi, Parviz K.
Hudson, Kayla
Machen, G. Luke
Barsky, Maya
Lebovic, Dan I.
Kavoussi, Shahryar K.
FSH levels and testicular volumes are associated with the severity of testicular histopathology in men with non-obstructive azoospermia
title FSH levels and testicular volumes are associated with the severity of testicular histopathology in men with non-obstructive azoospermia
title_full FSH levels and testicular volumes are associated with the severity of testicular histopathology in men with non-obstructive azoospermia
title_fullStr FSH levels and testicular volumes are associated with the severity of testicular histopathology in men with non-obstructive azoospermia
title_full_unstemmed FSH levels and testicular volumes are associated with the severity of testicular histopathology in men with non-obstructive azoospermia
title_short FSH levels and testicular volumes are associated with the severity of testicular histopathology in men with non-obstructive azoospermia
title_sort fsh levels and testicular volumes are associated with the severity of testicular histopathology in men with non-obstructive azoospermia
topic Reproductive Physiology and Disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8608933/
https://www.ncbi.nlm.nih.gov/pubmed/34532836
http://dx.doi.org/10.1007/s10815-021-02313-y
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