Mycoplasma infection and ocular surface diseases: a nationwide cohort study

Whether patients with Mycoplasma infection have an increased risk of ocular surface ulcers. Using a nation-wide database, we identified patients with a new diagnosis of Mycoplasma infection between 1997 and 2013, and compared them with age-, sex-, and index year-matched subjects without the infectio...

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Autores principales: Lai, Li-Ju, Chen, Vincent Chin-Hung, Yang, Yao-Hsu, Kao, Kai-Liang, Chen, Ko-Jung, Wang, Ying-Ching, Wu, Shu-I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8608996/
https://www.ncbi.nlm.nih.gov/pubmed/34811377
http://dx.doi.org/10.1038/s41598-021-01941-9
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author Lai, Li-Ju
Chen, Vincent Chin-Hung
Yang, Yao-Hsu
Kao, Kai-Liang
Chen, Ko-Jung
Wang, Ying-Ching
Wu, Shu-I
author_facet Lai, Li-Ju
Chen, Vincent Chin-Hung
Yang, Yao-Hsu
Kao, Kai-Liang
Chen, Ko-Jung
Wang, Ying-Ching
Wu, Shu-I
author_sort Lai, Li-Ju
collection PubMed
description Whether patients with Mycoplasma infection have an increased risk of ocular surface ulcers. Using a nation-wide database, we identified patients with a new diagnosis of Mycoplasma infection between 1997 and 2013, and compared them with age-, sex-, and index year-matched subjects without the infection. Cox proportional regression was performed to compare the risk of corneal diseases between the two cohorts. The incidence of corneal diseases was significantly higher in the 4223 patients with Mycoplasma infection than in the 16,892 patients without (7.28 vs. 5.94 per 1000 person-years, P < 0.01). The adjusted hazard ratio for the risk of corneal diseases in the study cohort was 1.21 times higher (95% CI 1.02–1.44) than that in the comparison cohort. Mycoplasma infection might be a predisposing factor for patients with keratitis.
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spelling pubmed-86089962021-11-24 Mycoplasma infection and ocular surface diseases: a nationwide cohort study Lai, Li-Ju Chen, Vincent Chin-Hung Yang, Yao-Hsu Kao, Kai-Liang Chen, Ko-Jung Wang, Ying-Ching Wu, Shu-I Sci Rep Article Whether patients with Mycoplasma infection have an increased risk of ocular surface ulcers. Using a nation-wide database, we identified patients with a new diagnosis of Mycoplasma infection between 1997 and 2013, and compared them with age-, sex-, and index year-matched subjects without the infection. Cox proportional regression was performed to compare the risk of corneal diseases between the two cohorts. The incidence of corneal diseases was significantly higher in the 4223 patients with Mycoplasma infection than in the 16,892 patients without (7.28 vs. 5.94 per 1000 person-years, P < 0.01). The adjusted hazard ratio for the risk of corneal diseases in the study cohort was 1.21 times higher (95% CI 1.02–1.44) than that in the comparison cohort. Mycoplasma infection might be a predisposing factor for patients with keratitis. Nature Publishing Group UK 2021-11-22 /pmc/articles/PMC8608996/ /pubmed/34811377 http://dx.doi.org/10.1038/s41598-021-01941-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Lai, Li-Ju
Chen, Vincent Chin-Hung
Yang, Yao-Hsu
Kao, Kai-Liang
Chen, Ko-Jung
Wang, Ying-Ching
Wu, Shu-I
Mycoplasma infection and ocular surface diseases: a nationwide cohort study
title Mycoplasma infection and ocular surface diseases: a nationwide cohort study
title_full Mycoplasma infection and ocular surface diseases: a nationwide cohort study
title_fullStr Mycoplasma infection and ocular surface diseases: a nationwide cohort study
title_full_unstemmed Mycoplasma infection and ocular surface diseases: a nationwide cohort study
title_short Mycoplasma infection and ocular surface diseases: a nationwide cohort study
title_sort mycoplasma infection and ocular surface diseases: a nationwide cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8608996/
https://www.ncbi.nlm.nih.gov/pubmed/34811377
http://dx.doi.org/10.1038/s41598-021-01941-9
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