Reconditioning the Neurogenic Niche of Adult Non-human Primates by Antisense Oligonucleotide-Mediated Attenuation of TGFβ Signaling

Adult neurogenesis is a target for brain rejuvenation as well as regeneration in aging and disease. Numerous approaches showed efficacy to elevate neurogenesis in rodents, yet translation into therapies has not been achieved. Here, we introduce a novel human TGFβ-RII (Transforming Growth Factor—Rece...

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Detalles Bibliográficos
Autores principales: Peters, Sebastian, Kuespert, Sabrina, Wirkert, Eva, Heydn, Rosmarie, Jurek, Benjamin, Johannesen, Siw, Hsam, Ohnmar, Korte, Sven, Ludwig, Florian Timo, Mecklenburg, Lars, Mrowetz, Heike, Altendorfer, Barbara, Poupardin, Rodolphe, Petri, Susanne, Thal, Dietmar R., Hermann, Andreas, Weishaupt, Jochen H., Weis, Joachim, Aksoylu, Inci Sevval, Lewandowski, Sebastian A., Aigner, Ludwig, Bruun, Tim-Henrik, Bogdahn, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609055/
https://www.ncbi.nlm.nih.gov/pubmed/33860461
http://dx.doi.org/10.1007/s13311-021-01045-2

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