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Sapropterin (BH4) Aggravates Autoimmune Encephalomyelitis in Mice

Depletion of the enzyme cofactor, tetrahydrobiopterin (BH4), in T-cells was shown to prevent their proliferation upon receptor stimulation in models of allergic inflammation in mice, suggesting that BH4 drives autoimmunity. Hence, the clinically available BH4 drug (sapropterin) might increase the ri...

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Detalles Bibliográficos
Autores principales:	Schmitz, Katja, Trautmann, Sandra, Hahnefeld, Lisa, Fischer, Caroline, Schreiber, Yannick, Wilken-Schmitz, Annett, Gurke, Robert, Brunkhorst, Robert, Werner, Ernst R., Watschinger, Katrin, Wicker, Sabine, Thomas, Dominique, Geisslinger, Gerd, Tegeder, Irmgard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609075/ https://www.ncbi.nlm.nih.gov/pubmed/33844153 http://dx.doi.org/10.1007/s13311-021-01043-4

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