Pleiotropic actions of IP6K1 mediate hepatic metabolic dysfunction to promote nonalcoholic fatty liver disease and steatohepatitis

OBJECTIVE: Obesity and insulin resistance greatly increase the risk of nonalcoholic fatty liver disease and steatohepatitis (NAFLD/NASH). We have previously discovered that whole-body and adipocyte-specific Ip6k1deletion protects mice from high-fat-diet-induced obesity and insulin resistance due to...

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Detalles Bibliográficos
Autores principales: Mukherjee, Sandip, Chakraborty, Molee, Ulmasov, Barbara, McCommis, Kyle, Zhang, Jinsong, Carpenter, Danielle, Msengi, Eliwaza Naomi, Haubner, Jake, Guo, Chun, Pike, Daniel P., Ghoshal, Sarbani, Ford, David A., Neuschwander-Tetri, Brent A., Chakraborty, Anutosh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609165/
https://www.ncbi.nlm.nih.gov/pubmed/34757046
http://dx.doi.org/10.1016/j.molmet.2021.101364

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