Altered neocortical oscillations and cellular excitability in an in vitro Wwox knockout mouse model of epileptic encephalopathy

Loss of function mutations of the WW domain-containing oxidoreductase (WWOX) gene are associated with severe and fatal drug-resistant pediatric epileptic encephalopathy. Epileptic seizures are typically characterized by neuronal hyperexcitability; however, the specific contribution of WWOX to that h...

Descripción completa

Detalles Bibliográficos
Autores principales: Breton, Vanessa L., Aquilino, Mark S., Repudi, Srinivasarao, Saleem, Afifa, Mylvaganam, Shanthini, Abu-Swai, Sara, Bardakjian, Berj L., Aqeilan, Rami I., Carlen, Peter L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609180/
https://www.ncbi.nlm.nih.gov/pubmed/34634460
http://dx.doi.org/10.1016/j.nbd.2021.105529

Ejemplares similares

Ejemplares similares