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Me(3)Al-mediated domino nucleophilic addition/intramolecular cyclisation of 2-(2-oxo-2-phenylethyl)benzonitriles with amines; a convenient approach for the synthesis of substituted 1-aminoisoquinolines

A simple and efficient protocol for the construction of 1-aminoisoquinolines was achieved by treating 2-(2-oxo-2-phenylethyl)benzonitriles with amines in the presence of Me(3)Al. The reaction proceeds via a domino nucleophilic addition with subsequent intramolecular cyclisation. This method provides...

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Detalles Bibliográficos
Autores principales:	Adusumalli, Krishna M S, Konidena, Lakshmi N S, Gandham, Hima B, Kumari, Krishnaiah, Valluru, Krishna R, Nidasanametla, Satya K R, Battula, Venkateswara R, Namballa, Hari K
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Beilstein-Institut 2021
Materias:	Letter
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609244/ https://www.ncbi.nlm.nih.gov/pubmed/34876930 http://dx.doi.org/10.3762/bjoc.17.186

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