Dendritic cell paucity in mismatch repair–proficient colorectal cancer liver metastases limits immune checkpoint blockade efficacy

Liver metastasis is a major cause of mortality for patients with colorectal cancer (CRC). Mismatch repair–proficient (pMMR) CRCs make up about 95% of metastatic CRCs, and are unresponsive to immune checkpoint blockade (ICB) therapy. Here we show that mouse models of orthotopic pMMR CRC liver metasta...

Descripción completa

Detalles Bibliográficos
Autores principales: Ho, William W., Gomes-Santos, Igor L., Aoki, Shuichi, Datta, Meenal, Kawaguchi, Kosuke, Talele, Nilesh P., Roberge, Sylvie, Ren, Jun, Liu, Hao, Chen, Ivy X., Andersson, Patrik, Chatterjee, Sampurna, Kumar, Ashwin S., Amoozgar, Zohreh, Zhang, Qixian, Huang, Peigen, Ng, Mei Rosa, Chauhan, Vikash P., Xu, Lei, Duda, Dan G., Clark, Jeffrey W., Pittet, Mikael J., Fukumura, Dai, Jain, Rakesh K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609309/
https://www.ncbi.nlm.nih.gov/pubmed/34725151
http://dx.doi.org/10.1073/pnas.2105323118

Ejemplares similares

Ejemplares similares