A Novel Recombinant Influenza Virus Neuraminidase Vaccine Candidate Stabilized by a Measles Virus Phosphoprotein Tetramerization Domain Provides Robust Protection from Virus Challenge in the Mouse Model

Current seasonal influenza virus vaccines do not induce robust immune responses to neuraminidase. Several factors, including immunodominance of hemagglutinin over neuraminidase, instability of neuraminidase in vaccine formulations, and variable, nonstandardized amounts of neuraminidase in the vaccin...

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Detalles Bibliográficos
Autores principales: Strohmeier, Shirin, Amanat, Fatima, Zhu, Xueyong, McMahon, Meagan, Deming, Meagan E., Pasetti, Marcela F., Neuzil, Kathleen M., Wilson, Ian A., Krammer, Florian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609353/
https://www.ncbi.nlm.nih.gov/pubmed/34809451
http://dx.doi.org/10.1128/mBio.02241-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609353/
https://www.ncbi.nlm.nih.gov/pubmed/34809451
http://dx.doi.org/10.1128/mBio.02241-21

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