Reprogrammed transsulfuration promotes basal-like breast tumor progression via realigning cellular cysteine persulfidation

Basal-like breast cancer (BLBC) is the most aggressive subtype of breast tumors with poor prognosis and limited molecular-targeted therapy options. We show that BLBC cells have a high Cys demand and reprogrammed Cys metabolism. Patient-derived BLBC tumors from four different cohorts exhibited elevat...

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Detalles Bibliográficos
Autores principales: Erdélyi, Katalin, Ditrói, Tamás, Johansson, Henrik J., Czikora, Ágnes, Balog, Noémi, Silwal-Pandit, Laxmi, Ida, Tomoaki, Olasz, Judit, Hajdú, Dorottya, Mátrai, Zoltán, Csuka, Orsolya, Uchida, Koji, Tóvári, József, Engebraten, Olav, Akaike, Takaaki, Børresen Dale, Anne-Lise, Kásler, Miklós, Lehtiö, Janne, Nagy, Péter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609449/
https://www.ncbi.nlm.nih.gov/pubmed/34737229
http://dx.doi.org/10.1073/pnas.2100050118

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