Bad Timing for Epileptic Networks: Role of Temporal Dynamics in Seizures and Cognitive Deficits

The precise coordination of neuronal activity is critical for optimal brain function. When such coordination fails, this can lead to dire consequences. In this review, I will present evidence that in epilepsy, failed coordination leads not only to seizures but also to alterations of the rhythmical p...

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Detalles Bibliográficos
Autor principal: Lenck-Santini, Pierre-Pascal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Current Review in Basic Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609592/
https://www.ncbi.nlm.nih.gov/pubmed/33724060
http://dx.doi.org/10.1177/15357597211001877
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author Lenck-Santini, Pierre-Pascal
author_facet Lenck-Santini, Pierre-Pascal
author_sort Lenck-Santini, Pierre-Pascal
collection PubMed
description The precise coordination of neuronal activity is critical for optimal brain function. When such coordination fails, this can lead to dire consequences. In this review, I will present evidence that in epilepsy, failed coordination leads not only to seizures but also to alterations of the rhythmical patterns observed in the electroencephalogram and cognitive deficits. Restoring the dynamic coordination of epileptic networks could therefore both improve seizures and cognitive outcomes.
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spelling pubmed-86095922021-12-02 Bad Timing for Epileptic Networks: Role of Temporal Dynamics in Seizures and Cognitive Deficits Lenck-Santini, Pierre-Pascal Epilepsy Curr Current Review in Basic Science The precise coordination of neuronal activity is critical for optimal brain function. When such coordination fails, this can lead to dire consequences. In this review, I will present evidence that in epilepsy, failed coordination leads not only to seizures but also to alterations of the rhythmical patterns observed in the electroencephalogram and cognitive deficits. Restoring the dynamic coordination of epileptic networks could therefore both improve seizures and cognitive outcomes. SAGE Publications 2021-03-16 /pmc/articles/PMC8609592/ /pubmed/33724060 http://dx.doi.org/10.1177/15357597211001877 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Current Review in Basic Science
Lenck-Santini, Pierre-Pascal
Bad Timing for Epileptic Networks: Role of Temporal Dynamics in Seizures and Cognitive Deficits
title Bad Timing for Epileptic Networks: Role of Temporal Dynamics in Seizures and Cognitive Deficits
title_full Bad Timing for Epileptic Networks: Role of Temporal Dynamics in Seizures and Cognitive Deficits
title_fullStr Bad Timing for Epileptic Networks: Role of Temporal Dynamics in Seizures and Cognitive Deficits
title_full_unstemmed Bad Timing for Epileptic Networks: Role of Temporal Dynamics in Seizures and Cognitive Deficits
title_short Bad Timing for Epileptic Networks: Role of Temporal Dynamics in Seizures and Cognitive Deficits
title_sort bad timing for epileptic networks: role of temporal dynamics in seizures and cognitive deficits
topic Current Review in Basic Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609592/
https://www.ncbi.nlm.nih.gov/pubmed/33724060
http://dx.doi.org/10.1177/15357597211001877
work_keys_str_mv AT lencksantinipierrepascal badtimingforepilepticnetworksroleoftemporaldynamicsinseizuresandcognitivedeficits

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