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Multiple Pathways of LRRK2-G2019S/Rab10 Interaction in Dopaminergic Neurons

BACKGROUND: Inherited mutations in the LRRK2 protein are common causes of Parkinson’s disease, but the mechanisms by which increased kinase activity of mutant LRRK2 leads to pathological events remain to be determined. In vitro assays (heterologous cell culture, phospho-protein mass spectrometry) su...

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Detalles Bibliográficos
Autores principales:	Fellgett, Alison, Middleton, C. Adam, Munns, Jack, Ugbode, Chris, Jaciuch, David, Wilson, Laurence G., Chawla, Sangeeta, Elliott, Christopher J.H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	IOS Press 2021
Materias:	Research Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609683/ https://www.ncbi.nlm.nih.gov/pubmed/34250948 http://dx.doi.org/10.3233/JPD-202421

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